Results 111 to 120 of about 1,695,279 (298)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

DMCpy: A powder and single crystal neutron diffraction software for the DMC diffractometer

SoftwareX
The recently upgraded DMC diffractometer at SINQ, Paul Scherrer Institute, Switzerland, equipped with a state-of-the-art 2D 3He detector, enables high-resolution neutron diffraction experiments optimized for both powder and single-crystal studies.
Jakob Lass, Samuel Harrison Moody, Øystein Slagtern Fjellvåg   +2 more
doaj   +1 more source

Technical Evaluation of Cutting Device for Volume Reduction of High Radio-Activated Instruments [PDF]

Proceedings of the 14th International Workshop on Spallation Materials Technology, 2020
Eiichi Wakai, Hideyuki Nemoto, Hidetaka Kinoshita, Takashi Wakui, Masahide Harada, Hiroshi Takada, Kouji Ishikawa   +6 more
openaire   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Real-time audio spectrum analysis and dynamic volume control system based on FFT

Egyptian Informatics Journal
Traditional sound mixers are often implemented using analog circuits, which have problems such as long response time and low adjustment accuracy. Therefore, this study designs a musical instrument tuning system based on Field Programmable Gate Array ...
Renjie Huang, Hongyang Huang
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Development and Application of Concentric Electric Downhole Measuring and Regulating Instrument

Shiyou jixie, 2016
To address the issues of multizone water injection in directional well like low success rate and efficiency of measuring and regulating and low precision of measuring and regulating small volume water injection,a concentric electric downhole measuring ...
Yu Jiuzheng, Ju Yafeng, Yang Lingzhi
doaj  

Thorium determination in seawater by inductively coupled plasma mass spectrometry: Method development and oceanographic applications

Talanta Open
Thorium isotopes in the ocean (including radiogenic isotopes and terrigenous-derived 232Th) serve as key tracers for studying land-derived material transport. While high-sensitivity and high-resolution inductively coupled plasma mass spectrometry (ICP-MS)
Yingjie Zou, Peng Wang, Lei Xu, Hong Ren, Yiyao Cao   +4 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source