Results 131 to 140 of about 422,503 (299)

Profiling the turbulent atmosphere and novel correction techniques for imaging and photometry in astronomy [PDF]

, 2010
The turbulent atmosphere has two detrimental effects in astronomy. The phase aberration induced by the turbulence broaden the point spread function (PSF) and limits the resolution for imaging.
OSBORN, JAMES
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

High-precision Galaxy Clustering Predictions from Small-volume Hydrodynamical Simulations via Control Variates

The Astrophysical Journal
Cosmological simulations of galaxy formation are an invaluable tool for understanding galaxy formation and its impact on cosmological parameter inference from large-scale structures.
Alexandra Doytcheva, Filomela V. Gerou, Johannes U. Lange   +2 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A new instrument for high statistics measurement of photomultiplier characteristics

, 2016
Since the early days of experimental particle physics photomultipliers (PMTs) have played an important role in the detector design. Thanks to their capability of fast photon counting, PMTs are extensively used in the new-generation of astroparticle ...
Mollo C. M., Pellegrino C., Di Capua F., Migliozzi P., Chiarusi T., Mele R., Bozza C., Costa M., Kulikovskiy V., Riccobene G., Vivolo D.   +10 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

W. R. Myers High School 2022

The annual publication of the students of W. R. Myers High School Taber, Alberta. (Volume 2021-2022)pdfW. R. MYERS HIGH SCHOOLPEOPLE............ STUDENT LIFE SPORTS........... GRAD............... ...pgs. 1-10 pgs. 10-45 pgs. 46-68 pgs.
W. R. Myers High School
core  

NASA’s PACE Ocean Color Instrument Thermal Design Evolution: from Goddard’s Instrument Design Lab Through Flight Development

, 2023
Kan Yang, NASA Goddard Space Flight Center, USADeepak Patel, NASA Goddard Space Flight Center, USAWes Ousley, NASA Goddard Space Flight Center, USAICES101: Spacecraft and Instrument Thermal SystemsThe 52nd International Conference on Environmental ...
Ousley, Wes, Patel, Deepak, Yang, Kan
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source