Results 131 to 140 of about 18,656,673 (304)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Low-power emulators of higher-order elements
, 2013 The thesis deals with emulating higher-order elements using the transformation mutators, which were described by Leon Chua in 1971. The procedure of designing mutators from their mathematical description to the synthesis of concrete electrical circuits ...
Teska, Tomáš
core +1 more source
Creative Activities and Students’ Higher Order Thinking Skills [PDF]
, 2010 This study investigated the effects of creative activities on high school chemistry students’ higher order thinking skills. Sixty (60) students were assigned randomly into Instruction with Creative Activities (ICA) group and Instruction with No ...
Ramirez, Rachel Patricia B. +1 more
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Canonical Higher-Order Kernels for Density Derivative Estimation [PDF]
In this note we present r th order kernel density derivative estimators using canonical higher-order kernels. These canonical rescalings uncouple the choice of kernel and scale factor. This approach is useful for selection of the order of the kernel in a
Christopher F. Parmeter +1 more
core
Higher order corrections to multijet production in e(^+)e(^-) annihilation [PDF]
, 1998 The analysis of hadronic events in high-energy electron-positron annihilation often relies upon the clustering of individual hadrons into energetic jets.
Campbell, John M.
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source