Results 111 to 120 of about 18,656,673 (304)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Hamilton’s Principle for Circuits with Dissipative Elements

Complexity, 2019
The classic form of Hamilton’s variational principle does not hold for circuits with dissipative elements. It is shown in the paper that this may not be true in the case of systems consisting of the so-called higher-order elements.
Zdeněk Biolek, Dalibor Biolek, Viera Biolková   +2 more
doaj   +1 more source

HOT [Higher Order Thinking Network newsletter]. #5. 2014: Summer.

, 2013
Quarterly; Began with issue 01 (spring 2013).; Newsletter of the Higher Order Thinking Schools Network.; Harvested from the web on 6/13 ...
Higher Order Thinking Schools Network (Conn.),
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The dynamics of higher-order novelties

Nature Communications
Studying how we explore the world in search of novelties is key to understand the mechanisms that can lead to new discoveries. Previous studies analyzed novelties in various exploration processes, defining them as the first appearance of an element ...
Gabriele Di Bona, Alessandro Bellina, Giordano De Marzo, Angelo Petralia, Iacopo Iacopini, Vito Latora   +5 more
doaj   +1 more source

ANALISIS KONTEN HOTS DALAM BUKU SIMPAY BASA SUNDA KELAS VIII

Magistra Andalusia
The goal of 21st century learning is that students are expected to have higher order thinking skills. But in fact, students' high-level thinking skills in Indonesia are still worrying.
Nugraha Mauludi, Nunuy Nurjanah, Retty Isnendes   +2 more
doaj   +1 more source

HOT [Higher Order Thinking Network newsletter]. #4. 2014: Spring.

, 2013
Quarterly; Began with issue 01 (spring 2013).; Newsletter of the Higher Order Thinking Schools Network.; Harvested from the web on 6/13 ...
Higher Order Thinking Schools Network (Conn.),
core  

Singular vector expansion functions for finite methods [PDF]

, 2005
This paper describes the fundamental properties of new singular vector bases that incorporate the edge conditions in curved triangular elements. The bases are fully compatible with the interpolatory or hierarchical high-order regular vector bases used in
Graglia, Roberto, Lombardi, Guido
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source