Results 41 to 50 of about 542,123 (286)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
A Unified Analysis of Fox H-Fading With Beam Misalignment: Theory and Applications
IEEE Open Journal of Vehicular Technology, 2023 This paper presents a unified analysis of the Fox H-fading channel with beam misalignment. A statistical framework is introduced that includes new expressions for the probability density function, cumulative distribution function, higher-order moments of
Hugerles S. Silva +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Reliability Evaluation of Cryogenic Shut-Off Valve Based on Weibull Segmented Model
Advances in Materials Science and Engineering, 2022 In order to improve the prediction accuracy of cryogenic shut-off valve failures and quantitatively analyze the distribution law of cryogenic shut-off valve failures, this study establishes a solution model based on genetic algorithm and statistics of ...
Yi Lu, Jian-Ming Zheng, Ting Chen
doaj +1 more source
Double Cuckoo Search Algorithm with Dynamically Adjusted Probability
Jisuanji kexue yu tansuo, 2021 Cuckoo search algorithm is an emerging bionic intelligent algorithm, which has the shortages of low search precision, easy to fall into local optimum and slow convergence speed. Double cuckoo search algorithm with dynamically adjusted probability (DECS)
CHEN Cheng, HE Xingshi, YANG Xinshe
doaj +1 more source
Higher-Order Laplace Equations and Hyper-Cauchy Distributions
, 2015 In this paper we introduce new distributions which are solutions of higher-order Laplace equations. It is proved that their densities can be obtained by folding and symmetrizing Cauchy distributions. Another class of probability laws related to higher-
Enzo Orsingher +3 more
core +1 more source