Results 51 to 60 of about 1,734,631 (265)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Quantum Magnetism of the Iron Core in Ferritin Proteins—A Re-Evaluation of the Giant-Spin Model

Molecules
The electron–electron, or zero-field interaction (ZFI) in the electron paramagnetic resonance (EPR) of high-spin transition ions in metalloproteins and coordination complexes, is commonly described by a simple spin Hamiltonian that is second-order in the
Wilfred R. Hagen
doaj   +1 more source

Higher-order term indexing using substitution trees [PDF]

ACM Transactions on Computational Logic, 2009
We present a higher-order term indexing strategy based on substitution trees for simply typed lambda-terms. There are mainly two problems in adapting first-order indexing techniques. First, many operations used in building an efficient term index and retrieving a set of candidate terms from a large collection are undecidable in general for higher-order
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Multi-parameter crack tip stress state description for estimation of fracture process zone extent in silicate composite WST specimens [PDF]

Fracture and Structural Integrity, 2013
For wedge splitting test specimens, the stress and displacement fields both in the vicinity and also in larger distance from the crack tip are investigated by means of numerical methods. Several variants of boundary conditions were modeled.
Václav Veselý, Jakub Sobek, Lucie Šestáková, Petr Frantík, Stanislav Seitl   +4 more
doaj   +1 more source

Pengembangan Buku Ajar Sejarah Fisika Berbasis Higher Order Thingking Skill (HOTS)

JPFT (Jurnal Pendidikan Fisika dan Teknologi), 2021
This study aims to develop and produce a physics history textbook based on higher order thinking skills (HOTS). This research was a development research which consists of four stages, namely: the determination stage, design, development, and ...
I Wayan Gunada, Syahrial Ayub, Aris Doyan, Ni Nyoman Sri Putu Verawati, Hikmawati Hikmawati   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Nested Term Graphs (Work In Progress) [PDF]

Electronic Proceedings in Theoretical Computer Science, 2015
We report on work in progress on 'nested term graphs' for formalizing higher-order terms (e.g. finite or infinite lambda-terms), including those expressing recursion (e.g. terms in the lambda-calculus with letrec).
Clemens Grabmayer, Vincent van Oostrom
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source