Results 81 to 90 of about 2,286,869 (360)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Stosunek lekarzy rodzinnych do interwencji związanych z używaniem alkoholu – polskie wyniki międzynarodowego projektu badawczego ODHIN

Alcoholism and Drug Addiction, 2015
Background: Brief interventions for alcohol use are considered an effective method of reducing alcohol drinking and alcohol-attributable mortality. The aim of the study was to document the attitudes of Polish general practitioners (GPs) to alcohol and ...
Andrzej Jakubczyk, Aneta Michalska, Natalia Szejko, Marcin Wojnar   +3 more
doaj   +1 more source

Motivation to drink alcohol in first year university students : having a good time or simply coping? [PDF]

, 2011
Research suggests that excessive alcohol consumption is a major health concern in undergraduates with typical drinking patterns established in the first year (Berwick, et al., 2008). While the stereotype is that students drink to have fun, some American
Macaskill, Ann, Mobach, Thomas
core  

Mortality post inpatient alcohol detoxification: a descriptive case series [PDF]

, 2013
<br>Background: Individuals with alcohol dependence often die prematurely. Scotland in particular has high rates of alcohol misuse compared to the rest of the UK and Europe.
Brodie, A., Langan-Martin, J., McLaughlin, A., Shajahan, P.   +3 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Alcohol affects neuronal substrates of response inhibition but not of perceptual processing of stimuli signalling a stop response [PDF]

, 2013
Alcohol impairs inhibitory control, including the ability to terminate an initiated action. While there is increasing knowledge about neural mechanisms involved in response inhibition, the level at which alcohol impairs such mechanisms remains poorly ...
A Green, A Hampshire, A Mehrabian, A Nambu, A Rey, AD Chevrier, AJ Caswell, AL Norman, AR Aron, AR Aron, AR Aron, AR Aron, AR Aron, BM Anderson, C Easdon, CA Marczinski, CA Marczinski, CA Marczinski, CD Chambers, CM Dodds, CM Steele, CN Boehler, CN Boehler, CN White, CR Guillot, CS Li, DJ Sharp, DM Dougherty, DM McCarthy, DM Torta, F Esposito, F Verbruggen, F Verbruggen, GD Logan, GE Alexander, GE Alexander, H de Wit, HM Duvernoy, Hugo Critchley, J Ashburner, J Chikazoe, J Weafer, JH Patton, JL Kenemans, JM Townshend, K Fromme, K Katanoda, K Marinkovic, K Nikolaou, K Rubia, KJ Friston, Kyriaki Nikolaou, L Boucher, LE Mulvihill, M Field, M Sano, MA Schuckit, Marcus Gray, MC Stevens, MT Fillmore, MT Fillmore, N Weiskopf, ND Volkow, NH Naqvi, R Deichmann, R Weissenborn, RB Buxton, RN Henson, RS Ross, RZ Goldstein, S Loeber, S Loeber, S Loeber, SC Matthews, SD Slotnick, T Duka, T Nichols, T Singer, Theodora Duka   +78 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Disinhibition and reward sensitivity in relation to alcohol consumption by university undergraduates [PDF]

, 2009
Deficits of prefrontal cortex functioning and associated executive cognitive impairments are well-known correlates of chronic alcoholism and may reflect cumulative effects of high alcohol exposure.
Czerczyk, Cameron, Follent, Anna, Lodge, Phoebe, Lyvers, Michael   +3 more
core   +2 more sources

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source