Results 91 to 100 of about 4,518,702 (324)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Stable categories of higher preprojective algebras
Advances in Mathematics, 2013 We introduce (n+1)-preprojective algebras of algebras of global dimension n. We show that if an algebra is n-representation-finite then its (n+1)-preprojective algebra is self-injective. In this situation, we show that the stable module category of the (n+1)-preprojective algebra is (n+1)-Calabi-Yau, and, more precisely, it is the (n+1)-Amiot cluster ...
Iyama, Osamu, Oppermann, Steffen
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
ESC Heart FailureAims The study aims to examine characteristics and outcomes associated with health‐related quality of life (HRQoL) in patients with heart failure (HF) with preserved, mildly reduced and reduced ejection fraction (EF) (HFpEF, HFmrEF and HFrEF).
Camilla Settergren +6 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Comment: 33 pages; contribution to Encyclopedia of Mathematical Physics, 2nd ...
openaire +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Diagrammatic sets and rewriting in weak higher categories [PDF]
, 2020 Amar Hadzihasanovic
openalex +1 more source
Framed Polytopes and Higher Categories
In the early 1990s, Kapranov and Voevodsky proposed a geometric method for constructing higher-categorical pasting diagrams from generically framed convex polytopes. This work revisits their construction and identifies a convex-geometric condition that is both necessary and sufficient for the procedure to yield a well-defined pasting diagram.
Laplante-Anfossi, G. +2 more
openaire +4 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source