Results 101 to 110 of about 16,459,303 (286)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Acknowledgement to 2015 reviewers

open access: yesCanadian Journal of Higher Education, 2016
Canadian Journal of Higher Education
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Acknowledgement to Reviewers

open access: yesCanadian Journal of Higher Education, 2015
Canadian Journal of Higher Education
doaj   +1 more source

Evaluation of mean glandular dose in relation to breast density in digital mammography

open access: yesThe Egyptian Journal of Radiology and Nuclear Medicine
Background Mammography is considered an ideal tool for breast cancer screening due to its proven effectiveness, which has led to its widespread use as the primary imaging modality for early detection.
Fatemeh Amiri   +7 more
doaj   +1 more source

Chatting or Cheating – Test of a First-Rate Intelligence?

open access: yesJournal of Ethics in Higher Education
The emergence of Large Language Models (LLMs) has significantly influenced the landscape of Higher Education, with their adoption by students and educators escalating rapidly since OpenAI introduced ChatGPT in November 2022.
Olivia Wilson   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Acknowledgement to reviewers

open access: yesCanadian Journal of Higher Education, 2014
Canadian Journal of Higher Education
doaj   +1 more source

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