Results 31 to 40 of about 15,910,979 (247)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Trends in quality management research in higher education institutions [PDF]
, 2016 The purpose of this study is to determine the state of research in quality management in higher education institutions based on a review of the academic literature.
Dick, Gavin +2 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Cell Death and DiseaseA subset of immature myeloid cells known as myeloid-derived suppressor cells (MDSCs) play an immunosuppressive role and actively stimulate the growth of tumors.
Jingwen Zhou +16 more
doaj +1 more source
Expression and Binding Characteristics of AoraPBP3 in Adoxophyes orana (Lepidoptera: Tortricidae)
BiologyAdoxophyes orana is a major leafroller pest that damages fruit trees from Asia to Central Europe. The sex pheromone (SP) of A. orana comprises Z9-14:Ac, Z11-14:Ac, Z9-14:OH, Z11-14:OH, and E9-14: Ac.
Shaoqiu Ren +6 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Operating and capital budgets for higher education
, 2005 Title from PDF cover (viewed July 6, 2007).; At head of title: Highlights.; "February 2005."; Previously published: FY 2003-05 mid-biennial operating & capital budgets for higher education / Board of Governors for Higher Education, Department of Higher ...
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
BMC GenomicsBackground Hypoxia significantly impairs tomato productivity and yield. Although cultivated tomato varieties (Solanum lycopersicum) are generally sensitive to low-oxygen conditions, their wild relatives (Solanum habrochaites) display substantially lower ...
Zhihan Zhang +8 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source