Results 91 to 100 of about 1,265,236 (304)

Experimental study of coconut (Cocos nucifera) waste through densification to obtain pellets and briquettes

Revista Facultad de Ingeniería Universidad de Antioquia
In Ecuador, extensive coconut (Cocos nucifera) harvesting generates large quantities of waste, including husks, shells, and fibers, posing environmental and economic challenges.
Luis Velázquez-Araque, Jonathan Teneta-Ibarra, Fernando Sáenz-Gómez   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

ASCA X-ray observations of the disk wind in the dwarf nova Z Camelopardalis [PDF]

, 2001
We present ASCA observations of the dwarf nova Z Camelopardalis during outburst and during a transition from quiescence to another outburst. At the beginning of the transition the X-ray count rate was an order of magnitude higher and the spectrum much ...
Anders, Arnaud, Cordova, Cordova, D.S. Baskill, Done, J.P. Osborne, Knigge, Liedahl, Mason, Mauche, Mewe, Mewe, Morrison, Mukai, Mukai, P.J. Wheatley, Patterson, Patterson, Pringle, Pringle, Pringle, Proga, Pye, Randich, Ritter, Tanaka, Warner, Wheatley, Wheatley   +29 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The mean ionic charge of silicon in 3HE-rich solar flares [PDF]

Mean ionic charge of iron in 3He-rich solar flares and the average mean charge of Silicon for 23 #He-rich periods during the time interval from September 1978 to October 1979 were determined.
Hovestadt, E., Klecker, B., Luhn, A., Moebius, E.   +3 more
core   +1 more source

Phenomenological characterization of sequential dual-curing of off-stoichiometric "thiol-epoxy" systems: Towards applicability [PDF]

, 2017
An extensive characterization of a sequential dual-curing system based on off-stoichiometric “thiol-epoxy” mixtures was carried out using thiol compounds of different functionality.
Belmonte, Alberto, Fernández Francos, Xavier, Flor López, Sílvia de la, Serra Albet, Àngels   +3 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Modeling the Higher Heating Value of Spanish Biomass via Neural Networks and Analytical Equations

Energies
Accurate estimation of biomass higher heating value (HHV) is crucial for designing efficient bioenergy systems. In this study, we developed a Backpropagation artificial neural network (ANN) that predicts HHV from routine proximate/ultimate composition ...
Anbarasan Jayapal, Fernando Ordonez Morales, Muhammad Ishtiaq, Se Yun Kim, Nagireddy Gari Subba Reddy   +4 more
doaj   +1 more source