Results 131 to 140 of about 12,698,759 (344)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Higher-Order-Schmidt-Representations and their Relevance for the Basis-Ambiguity [PDF]
, 2010 Manfred Requardt
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HIGHER-ORDER LORENTZ VIOLATION [PDF]
, 2014 Presented at the Sixth Meeting on CPT and Lorentz Symmetry, Bloomington, Indiana, June 17-21 ...
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Higher Order Hadronic Energy Level Shifts in Protonium [PDF]
, 1998 Xinwei Kong, F. Ravndal
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IEEE Transactions on Information TheoryWe generalize staircase codes and tiled diagonal zipper codes, preserving their key properties while allowing each coded symbol to be protected by arbitrarily many component codewords rather than only two. This generalization which we term "higher-order staircase codes" arises from the marriage of two distinct combinatorial objects: difference triangle
Mohannad Shehadeh +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Journal of Algebra, 2001 This article is about certain properties of higher order polars of a germ of complex analytic curve \(C\), say defined near the origin of \(\mathbb{C}^2\) by a convergent power series \(f(x,y)\). Recall that the first \(x\)-polar of \(f\) is the germ \(P_x(f)\) defined by the analytic equation \(\partial f/ \partial y=0\).
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