Results 131 to 140 of about 19,827,130 (305)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Higher education: faculty work [PDF]

, 1995
Oregon State System of Higher EducationTitle from PDF cover (viewed on April 2, 2024)This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

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Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The topic of disease in the text discussions of Russian citizens assigned to provide primary health care in rural areas

Siberian Journal of Life Sciences and Agriculture
Background. Modern scientific rationality in studying the understanding and attitude of the individual to illness is characterized by the interaction of various approaches to the study of linguistic formations.
Olga V. Mitrofanova, Svetlana V. Piskunova, Larisa V. Frolova   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Visual analytics of higher order information for trajectory datasets

, 2013
Due to the widespread of mobile sensing, there is a strong need to handle trails of moving objects, and trajectories. This paper proposes three visual analytics approaches for higher order information of trajectory datasets based on the higher order ...
Lee, Ickjai, Wang, Ye
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HISTORICAL AND TOPOGRAPHIC MODELING THE FIRST SIEGE OF THE ALBAZINSKY PRISON. II

Вестник Брянского государственного университета
This material is the second part in a series of articles describing the first siege of the state-owned Albaza prison in June 1685. The paper presents a description of the numerical number and composition of artillery of the ground forces and warships of ...
Lokhov A.Y., Eremin I.E., Natsvin A.V.
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

HISTORICAL AND ARCHAEOLOGICAL MODELING OF THE ALBAZIN FORT DURING THE SECOND SIEGE. III

Вестник Брянского государственного университета
In previous works, the authors presented 3D models of artillery bastions, a powder magazine and dugouts. However, for the most complete three-dimensional visualization of the Albaza fortress, it was necessary to develop three–dimensional models of its ...
Lokhov A.Yu., Eremin I. E., Natsvin A.V.   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source