Results 41 to 50 of about 1,751,206 (262)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Black Hole Thermodynamics and Generalized Uncertainty Principle with Higher Order Terms in Momentum Uncertainty

Advances in High Energy Physics, 2018
We study the modification of thermodynamic properties of Schwarzschild and Reissner-Nordström black hole in the framework of generalized uncertainty principle with correction terms up to fourth order in momentum uncertainty. The mass-temperature relation
Sunandan Gangopadhyay, Abhijit Dutta
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Global attractivity of a higher order nonlinear difference equation with decreasing terms

Electronic Journal of Qualitative Theory of Differential Equations
In the present paper, we further study the asymptotical behavior of the following higher order nonlinear difference equation \begin{equation*} x(n+1)= ax(n)+ bf( x(n)) + cf(x(n-k)), \qquad n=0, 1, \dots \end{equation*} where $a, b $ and $c$ are constants
Xiao Wang, Chuanxi Qian
doaj   +1 more source

A Transfinite Knuth–Bendix Order for Lambda-Free Higher-Order Terms

, 2017
We generalize the Knuth–Bendix order (KBO) to higher-order terms without λ-abstraction. The restriction of this new order to first-order terms coincides with the traditional KBO. The order has many useful properties, including transitivity, the subterm property, compatibility with contexts (monotonicity), stability under substitution, and well ...
Becker, Heiko, Blanchette, Jasmin, Waldmann, Uwe, Wand, Daniel   +3 more
openaire   +5 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Solutions of a System of Two Higher-Order Difference Equations in Terms of Lucas Sequence

Universal Journal of Mathematics and Applications, 2019
In this paper we give some theoretical explanations related to the representation for the general solution of the   system of the  higher-order rational difference equations $$ x_{n+1} = \frac{5 y_{n-k}-5}{y_{n-k}}, \qquad y_{n+1} = \frac{5 x_{n-k}-5}{x_{
Amira Khelifa, Yacine Halim, Massaoud Berkal   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Renormalization group equations and the recurrence pole relations in pure quantum gravity

Nuclear Physics B, 2021
In the framework of dimensional regularization, we propose a generalization of the renormalization group equations in the case of the perturbative quantum gravity that involves renormalization of the metric and of the higher order Riemann curvature ...
Sergey N. Solodukhin
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source