Results 81 to 90 of about 297,937 (262)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Objective Priors for Invariant e-Values in the Presence of Nuisance Parameters
EntropyThis paper aims to contribute to refining the e-values for testing precise hypotheses, especially when dealing with nuisance parameters, leveraging the effectiveness of asymptotic expansions of the posterior. The proposed approach offers the advantage of
Elena Bortolato, Laura Ventura
doaj +1 more source
The Bayesian Score Statistic [PDF]
, 2000 We propose a novel Bayesian test under a (noninformative) Jeffreys’ prior specifica- tion. We check whether the fixed scalar value of the so-called Bayesian Score Statistic (BSS) under the null hypothesis is a plausible realization from its known and ...
Kleibergen, F.R. (Frank) +2 more
core +1 more source
Modeling the HeII Transverse Proximity Effect: Constraints on Quasar Lifetime and Obscuration
, 2017 The HeII transverse proximity effect - enhanced HeII Ly{\alpha} transmission in a background sightline caused by the ionizing radiation of a foreground quasar - offers a unique opportunity to probe the emission properties of quasars, in particular the ...
Davies, Frederick B. +5 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
, 2016 We present a method to simultaneously model the dust far-infrared spectral energy distribution (SED) and the total infrared $-$ carbon monoxide (CO) integrated intensity $(S_{\rm IR}-I_{\rm CO})$ relationship.
Cormier, Diane +8 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
MathematicsThis paper develops simultaneous confidence intervals (SCIs) for pairwise differences of means with zero-inflated Rayleigh (ZIR) distributions, a flexible framework for modeling positively skewed data with excess zeros.
Warisa Thangjai +3 more
doaj +1 more source