Results 131 to 140 of about 106,214 (290)

Oral candidiasis as a clinical marker of highly active antiretroviral treatment failure in HIV-infected patients

Infectio
Introduction: Oral candidiasis is an opportunistic infection that is readily detectable in the clinic. It has been used to assess the immune status of HIV patients as well as the effectiveness of highly active antiretroviral therapy.
Sandra Lopez-Verdin, Amalia Torrecilla-Ramirez, Ana Cristina Horta-Sandoval, Jaime Federico Andrade-Villanueva, Ronell Bologna-Molina   +4 more
doaj   +1 more source

Etiologic Characteristics of Enterocolitis in Hospitalized HIV-Infected Patients for 3-Year Period (2013-2015)

Acta Medica Bulgarica, 2016
Diarrhea is the most common gastrointestinal symptom in HIV-infected patients. The incidence and severity of diarrhea increase with progression of the immune defi ciency.
Yancheva N., Strashimirov D., Elenkov I., Tchervenyakova T., Tomova P., Tcvetkova N., Yankova M., Tomov T., Nikolova M.   +8 more
doaj   +1 more source

Contemporary Disengagement From Antiretroviral Therapy in the Western Cape, South Africa: A Cross‐Sectional Study

Journal of the International AIDS Society, Volume 29, Issue 5, May 2026.
ABSTRACT Introduction South Africa has the largest antiretroviral therapy (ART) programme in the world, with universal access available through the public health system. Yet, gaps in coverage persist. In the Western Cape (WC), an estimated 200,000 people living with HIV are not currently on ART—many of whom are known to the health services.
Jonathan Euvrard, Claire Marriott Keene, Erin von der Heyden, Meg Osler, David Pienaar, Hassan Mahomed, Graeme Meintjes, Mary‐Ann Davies, Andrew Boulle   +8 more
wiley   +1 more source

Primary care for diabetes in HIV-infected patients [PDF]

, 2007
Diabetes mellitus (DM) is a common disorder affecting individuals of all ages. Similar to general population, DM can also be seen in HIV infected cases.
Wiwanitkit, Viroj
core   +1 more source

Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients [PDF]

, 2016
Raymond A. Tetteh, Edmund T. Nartey, Margaret Lartey, Aukje K. Mantel‐Teeuwisse, Hubert G. M. Leufkens, Barbara A Yankey, Alexander Dodoo   +6 more
openalex   +1 more source

2025 Consensus Clinical Management Guidelines for Niemann‐Pick Disease Type C

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT In 2018, the International Niemann‐Pick Disease Alliance (INPDA) and the International Niemann‐Pick Disease Registry (INPDR) developed and published comprehensive clinical management guidelines to support inclusive and standardized care pathways in Niemann‐Pick disease type C (NPC)—an ultra‐rare, autosomal recessive, neurovisceral lysosomal ...
Tarekegn Hiwot, Forbes D. Porter, Tatiana Bremova‐Ertl, Uma Ramaswami, Caroline Hastings, Bénédicte Héron, Justin Hopkin, Joella Melville, Hernan Amartino, Mireia del Toro, Federica Deodato, Fatih Ezgü, Paul Gissen, James B. Gibson, Can Ficicioglu, Roberto Giugliani, Orna Staretz‐Chacham, Frances Platt, Nathalie Guffon, Kristina Julich, Nikola Kresojević, Anna Lehman, Yann Nadjar, Susanne A. Schneider, Simon Jones, Eugen Mengel, Michel Tchan, Mark Walterfang, Ozlem Goker‐Alpan, Charlotte Dawson, Sandra Cowie, Toni Mathieson, Elizabeth Berry‐Kravis, Marc C. Patterson   +33 more
wiley   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, Efficacy and Drug Resistance Selection of Injectable Long‐Acting Lenacapavir Pre‐Exposure Prophylaxis (PrEP) Against HIV

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Oral pre‐exposure prophylaxis (PrEP) can substantially reduce HIV infection risk when taken as prescribed. However, many individuals struggle adhering to the daily regimen. Twice‐yearly injections of the novel HIV capsid inhibitor lenacapavir (LEN) demonstrated potential in recent PrEP trials.
Hee‐yeong Kim, Antonia Liebenberg, Lanxin Zhang, Max von Kleist   +3 more
wiley   +1 more source

An Interactive Pharmacokinetic‐Pharmacodynamic Framework to Evaluate Bedaquiline Dose Modifications in Adults With Tuberculosis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Bedaquiline is approved for use in a thrice‐weekly dosing schedule; simpler once‐daily dosing strategies could enable fixed‐dose combinations and improve patient adherence. We developed an interactive R Shiny simulation tool to enable the evaluation of different bedaquiline dosing schedules within an integrated dose‐pharmacokinetic‐efficacy ...
Yu‐Jou Lin, Frances Okibedi, Mats O. Karlsson, Elin M. Svensson   +3 more
wiley   +1 more source

Retrotransposons in Bone and Joint Diseases

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
This graphical abstract illustrates how epigenetic erosion during aging and disease reactivates retrotransposons, particularly endogenous retroviruses (ERVs), in musculoskeletal tissues. Their activation induces viral and molecular mimicry, triggering innate and adaptive immune responses and promoting cellular senescence.
Ye Liu, H. Josh Jang, Tao Yang
wiley   +1 more source