Results 51 to 60 of about 8,379,611 (261)

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy. [PDF]

, 2014
The objective of this study is to estimate life expectancies of HIV-positive patients conditional on response to antiretroviral therapy (ART)
Richard Gilson, Margaret T. May, John Walsh, Chadwick, D, Gompels, Mark, Porter, Kholoud, Anderson, Jane, Delpech, V, UK, UKCHIVC, Leen, Clifford, Martin, F, Valerie Delpech, Sophie Jose, Hill, Teresa, Jose, Sophie, Pillay, Deenan, Sabin, Caroline, Chloe Orkin, Orkin, Chloe, Fabiola Martin, UK Collaborative HIV Cohort (UK CHIC) Study, ., Sabin, C, Hay, Phillip, Johnson, M, Martin Fisher, Gilson, Richard, Kholoud Porter, Fisher, M, Ainsworth, Jonathan, ?, ?, Johnson, Margaret, Gilson, R, Hay, P, Gompels, M, Phillip Hay, Nelson, Mark, Palfreeman, Adrian, Teresa Hill, Phillips, Andrew, Mackie, Nicky, Porter, K, May, Margaret T, Delpech, Valerie, Mark Nelson, UK Collaborative HIV Cohort (UK CHIC) Study, Fisher, Martin, Walsh, J, Babiker, Abdel, Hill, T, Schwenk, Achim, Adrian Palfreeman, Chadwick, David, Orkin, C, Winston, Alan, Ainsworth, J, Kegg, Stephen, Margaret Johnson, David Chadwick, Caroline Sabin, Walsh, John, Sachikonye, Memory, Nelson, M, Kegg, S, May, MT, Frank Post, Clifford Leen, Martin, Fabiola, Dunn, Daviad, Anderson, J, Gazzard, Brian, Post, Frank, Mark Gompels, Jose, S, May, Margaret T., Post, F, Palfreeman, A, Leen, C, Stephen Kegg, Jonathan Ainsworth, Jane Anderson   +79 more
core   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

Prevalence, correlates and under-diagnosis of clinical depression among adults on highly active antiretroviral therapy in a Tertiary Health Institution in northeastern Nigeria

Journal of Public Health in Africa, 2014
Clinical depression is a highly debilitating illness, which is often under-diagnosed and negatively impacts on the quality of life of its sufferers. When it co-exists with other medical conditions, its effect is even more incapacitating.
Abdu Wakawa Ibrahim, Mohammed Said Jidda, Musa Abba Wakil, Isa Bukar Rabbebe, Asuku Beida Omeiza, Haruna Yusuph, Adegboyega Ogunlesi, Umar Garba Suleiman   +7 more
doaj   +1 more source

B/ordering and healthcare access for migrants with precarious status: The role of healthcare workers in counteracting restrictive policies

American Journal of Community Psychology, EarlyView.
Abstract In Canada, precarious migration is largely invisibilized. Nonetheless, b/ordering greatly affects people's realities by limiting access to social rights. In Quebec, migrants with precarious status (MPS) do not have access to healthcare, although Quebec has a “universal” healthcare coverage.
Émilie Pigeon‐Gagné, Jill Hanley, Élise Bourgeois‐Guérin, Pénélope Boudreault   +3 more
wiley   +1 more source

Cost analysis of initial highly active antiretroviral therapy regimens for managing human immunodeficiency virus-infected patients according to clinical practice in a hospital setting

Therapeutics and Clinical Risk Management, 2013
Giorgio L Colombo,1,2 Antonella Castagna,3 Sergio Di Matteo,2 Laura Galli,3 Giacomo Bruno,2 Andrea Poli,3 Stefania Salpietro,3 Alessia Carbone,3 Adriano Lazzarin3,41Department of Drug Sciences, School of Pharmacy, University of Pavia, Italy; 2Studi ...
Colombo GL, Castagna A, Di Matteo S, Galli L, Bruno G, Poli A, Salpietro S, Carbone A, Lazzarin A   +8 more
doaj  

Effect of antiretroviral therapy on lipid profile in newly diagnosed HIV-infected children of immune stage III and IV

CHRISMED Journal of Health and Research, 2022
Background: There are increasing concerns about the adverse effects of highly active antiretroviral therapy (HAART) on lipid profiles. Limited studies reported the adverse effects of HAART on lipid profiles from the Indian subcontinent.
Neelam Singh, Vijendra Kumar Garg, Rohitash Meena, Rambabu Sharma, Sunil Gothwal   +4 more
doaj   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Lipodystrophy and metabolic parameters of people living with HIV

DST, 2018
Introduction: Since the earliest reported cases in the United States, Acquired Immunodeficiency Syndrome (AIDS) remains one of the major challenges to global health.
Labibe do Socorro Haber de Menezes, Khayro Lima dos Reis, Michel Douglas Silva de Sousa, Diego de Aviz Gonçalves, Manfried Cleiton Mendes Rocha, Rosana Maria Feio Libonati   +5 more
doaj  

Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study [PDF]

, 2005
Objectives To investigate whether there is evidence that an increasing proportion of HIV infected patients is starting to experience increases in viral load and decreases in CD4 cell count that are consistent with exhaustion of available treatment ...
Youle, M S, Mike S Youle (16122224), Philippa Easterbrook (70407), UK CHIC Study Grp, Phillips, AN, Sanjay Bhagani (300128), Youle, MS, Scullard, G, Ryanne Matthias (16122221), Richard Gilson (125405), Andrew N Phillips (3559133), Caroline A Sabin (8085905), Hill, T, Teresa Hill (16119995), Martin Fisher (300134), Gazzard, B, Sabin, CA, Brian Gazzard (4921), Lampe, F, Fisher, M, George Scullard (16122227), Phillips, A N, Fiona Lampe (282424), Johnson, MA, Easterbrook, P, Gilson, R, Margaret A Johnson (16120793), Sabin, C A, Bhagani, S, Matthias, R, Johnson, M A   +30 more
core   +1 more source