Results 71 to 80 of about 106,214 (290)

HIV treatment as prevention : models, data, and questions-towards evidence-based decision-making [PDF]

, 2012
Antiretroviral therapy (ART) for those infected with HIV can prevent onward transmission of infection, but biological efficacy alone is not enough to guide policy decisions about the role of ART in reducing HIV incidence.
Delva, Wim, HIV Modelling Consortium Treatment as Prevention Editorial Writing Group, The   +1 more
core   +2 more sources

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, EarlyView.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadari, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source

Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion

Annals of Hepatology, 2019
Immune reconstitution syndrome is a recognized complication with initiation of highly active antiretroviral therapy for acquired immune deficiency syndrome patients co-infected with hepatitis B.
Michael W. Rowley, Amitkumar Patel, Wendi Zhou, Mark Wong, Anil B. Seetharam   +4 more
doaj   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Association of Tenofovir Use With Risk of Incident Heart Failure in HIV-Infected Patients. [PDF]

, 2017
BackgroundThe antiretroviral medication, tenofovir disoproxil fumarate (TDF), is used by most human immunodeficiency virus-infected persons in the United States despite higher risks of chronic kidney disease.
Chen, Ruijun, Estrella, Michelle M, Grunfeld, Carl, Horberg, Michael A, Hsue, Priscilla Y, Jotwani, Vasantha, Scherzer, Rebecca, Shlipak, Michael G   +7 more
core   +1 more source

Beyond Standard Half‐Life: Real‐world Pharmacokinetics of Efanesoctocog Alfa in a Single Centre

Haemophilia, EarlyView.
ABSTRACT Introduction Efanesoctocog alfa (EFA) is an ultra–extended half‐life factor VIII (FVIII) developed to address limitations of conventional prophylaxis in haemophilia A. Although the XTEND trials reported low interindividual pharmacokinetic (PK) variability, real‐world data remain important to better characterize PK profiles across patient ...
Laurent Sattler, Agathe Herb, Léa Pierre, Jordan Wimmer, Manon Dolt, Olivier Feugeas, Dominique Desprez   +6 more
wiley   +1 more source

Comparison of the effectiveness of initial combined antiretroviral therapy with nelfinavir or efavirenz at a university-based outpatient service in Brazil

Brazilian Journal of Medical and Biological Research, 2007
Since there are some concerns about the effectiveness of highly active antiretroviral therapy in developing countries, we compared the initial combination antiretroviral therapy with zidovudine and lamivudine plus either nelfinavir or efavirenz at a ...
T. Vanni, K.M. Morejón, R.C. Santana, L. de Melo, S.B.R.L. Ferrão, A.P. Amorim, G.G. Gaspar, C.C. Ponzi, N.A. Golin, F.L. Custódio, A.T.D. Marangoni, C.P. Campos Jr., B.A.L. Fonseca   +12 more
doaj   +1 more source

Understanding the implementation of patient navigation for adults living with HIV: A scoping review of components, equity considerations and lessons learned

HIV Medicine, EarlyView.
Abstract Background People living with HIV navigate complex medical and social challenges that impact engagement in care, including stigma, poverty and systemic inequities. Patient navigation has emerged as a promising approach to improve linkage, retention and adherence across the HIV care continuum.
Kristina M. Kokorelias, Christine L. Sheppard, Andrew Eaton, Marina B. Wasilewski, Sander L. Hitzig, Dean Valentine, Mackenzie Earle, Carolina Navas, David Gerstle, Maurita T. Harris, Luxey Sirisegaram   +10 more
wiley   +1 more source

Providing antiretroviral care in conflict settings. [PDF]

, 2009
There has been an historic expectation that delivering combination antiretroviral therapy (cART) to populations affected by violent conflict is untenable due to population movement and separation of drug supplies. There is now emerging evidence that cART
Eyawo, Oghenowede, Ford, Nathan, Mills, Edward J, Singh, Sonal   +3 more
core   +2 more sources

Missed opportunities to prevent HIV acquisition with pre‐exposure prophylaxis: A mixed methods study of people with recently acquired HIV in the United Kingdom

HIV Medicine, EarlyView.
Abstract Objectives To explore missed opportunities for PrEP use among people with recently acquired HIV in the United Kingdom. Methods Data were derived from CASCADE, an international, longitudinal, mixed‐methods study of adults (≥16 years) with recently acquired HIV (≤12 months).
Argyro Karakosta, Emily Jay Nicholls, Flavien Coukan, Diarmuid Nugent, Iain Reeves, Laura Waters, Sarah Fidler, Elisa Ruiz Burga, Julie Fox, Alison Uriel, Jane Nicholls, Claire Mackintosh, Shema Tariq, Fiona Burns, for CASCADE Collaboration, John Gill, Kholoud Porter, Fiona Burns, Christina Carlander, Rafael Eduardo Campo, Harmony Garges, Sophie Grabar, Inma Jarrín, Laurence Meyer, Moustafa Kamel, Shema Tariq, Giota Touloumi, Marc van der Valk, Vani Vannappagari, Alain Volny Anne, Linda Wittkop, Lital Young, Agnes Aisam, Diana Barger, Eli Fitzgerald, Argyro Karakosta, Emily Jay Nicholls, Nicoletta Policek, Bruno Spire, Inés Suárez‐García, Sophie Abgrall, Valerie Andriantsoanirina, Veronique Avettand‐Fenoel, Christine Bourgeois, Marie‐Laure Chaix, Antoine Cheret, Hugues Fischer, Cecile Goujard, Caroline Lascoux‐Combe, Annie Le Palec, Ventzlislava Petrov‐Sanchez, Asier Saez‐Cirion, Remonie Seng, Karl Stefic, Josephine Tine, E Piet, A Gagneux‐Brunon, C Jacomet, L Piroth, F Benezit, M Goussef, P Tattevin, F Bani Sadr, I Lamaury, M Nacher, H Bazus, O Robineau, R Calin, C Katlama, JL Meynard, B Denis, J Ghosn, V Joly, MA Khuong, F Caby, E Rouveix Nordon, P de Truchis, S Abgrall, A Chéret, C Duvivier, A Becker, P Miailhes, S Abel, G Unal, A Makinson, G Martin‐Blondel, A Morisot, S Bregigeon, C Allavena, V Rabier, H Fischer, L Vallet, L Marchand, T Saïdi, D Costagliola, S Grabar, Pierre Tattevin, Pierre de Truchis, M Hughes Fischer, Santiago Moreno, David Dalmau, M Luisa Navarro, M Isabel González, Federico Garcia, Eva Poveda, Félix Gutiérrez, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M Ángeles Muñoz‐Fernández, G. Adamis, M. Chini, G. Chrysos, M. Marangos, O. Katsarou, D. Kofteridis, S. Metallidis, P. Panagopoulos, N. Pantazis, A. Papadopoulos, V. Paparizos, V. Papastamopoulos, M. Psychogiou, H. Sambatakou, NV. Sipsas, G. Touloumi, C Thomadakis, Julie Fox, Louise Terry, Alison Uriel, Sarah Fidler, Wilbert Ayap, Laura Waters, Fowsiya Nur, Sabine Kinloch, Thomas Fernandez, Diarmuid Nugent, Javier Pinedo, Iain Reeves, Lidia Ignatov, Tracy Fong, Laura Cunningham, Jaydee Pangan, Claire Mackintosh, Louise Sharp   +145 more
wiley   +1 more source