Results 181 to 190 of about 96,616 (241)

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Efficacy and safety of monoclonal antibodies in the treatment of relapsing remitting multiple sclerosis: a systematic review. [PDF]

J Neurol
Avedillo-Salas A, Martínez LB, Fanlo-Villacampa A, Vicente-Romero J.   +3 more
europepmc   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Long-term outcomes of autologous haematopoietic stem cell transplantation in multiple sclerosis: A retrospective single-centre experience. [PDF]

Mult Scler J Exp Transl Clin
Malucchi S, De Gobbi M, Malentacchi M, Ulisciani S, Ascenzi C, Bertolotto A, Di Sapio A.   +6 more
europepmc   +1 more source

Lacosamide-Responsive Paroxysmal Tonic Spasms Associated With a New Lateral Cerebral Peduncle Lesion in Multiple Sclerosis: A Case Report. [PDF]

Cureus
Amanallah MR, Benzakour H, Zakaria Y, Balili K, Chraa M, Louhab N.   +5 more
europepmc   +1 more source

PET imaging of microglial pathology in multiple sclerosis. [PDF]

Curr Opin Neurol
Hartiala O, Tuomaala J, Airas L.
europepmc   +1 more source

Iron accumulation in multiple sclerosis and implications for cognitive and clinical progression: a systematic review of advanced neuroimaging studies. [PDF]

J Neurol
Susinna C, Restuccia G, Triolo G, Marafioti G, Cammaroto S, Sessa E, D'Aleo G, Quartarone A, Lo Buono V.   +8 more
europepmc   +1 more source

Anti-Inflammatory Properties of Curcumin as Add-On Therapy in Patients with MS-Prospective, Comparative, Randomized, Pilot Study. [PDF]

Pharmaceutics
Kukushkina A, Rogovskii V, Zhilenkova O, Sadekov T, Melnikov M, Boyko A.   +5 more
europepmc   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

18:2 Cholesterol Ester is a Novel Prognostic Biomarker of Disease Progression in Multiple Sclerosis. [PDF]

Mol Neurobiol
Torres P, Sánchez AG, Sancho-Saldaña A, Quibus L, San Pedro Murillo E, Ruiz-Fernández E, Peralta S, Solana MJ, Brieva L, González-Mingot C.   +9 more
europepmc   +1 more source