Results 71 to 80 of about 1,126,107 (137)

Senescent macrophages in tumor: phenotypes, roles, and interventions

Cell Death and Disease
The senescence of immune cells, including macrophages, that accompany the initiation and development of tumors has become a novel research hotspot. Recently, studies have reported the molecular characteristics of senescent macrophages (sMACs) in the ...
Wenhui Shen, Yueyu Huang, Xuping Yang, Yutian Zhang, Yiyi Pan, You Xiao, Jiahui Wang, Changchun Wang, Weimin Mao, An Zhao   +9 more
doaj   +1 more source

Development of Manganese Carbonyl Loaded Upconversion Nanoparticles for Near‐Infrared‐Triggered Carbon Monoxide and Mn2+ Delivery

Advanced NanoBiomed Research
Photoactivatable carbon monoxide‐releasing molecules (CORMs), typically based on transition‐metal carbonyl complexes, have reliance on activation by UV or visible light that restricts their biomedical applications.
Yile Zheng, Yi Wei, Yuying Yang, Xiang Wen, Cai Yang, Yating Xiao, Zhen Du, Xiangsheng Liu   +7 more
doaj   +1 more source

Cisplatin Promotes Immunosuppression in Ovarian Cancer by Enhancing miR‐181a‐5p‐Enriched Extracellular Vesicles to Drive Regulatory T Cell Differentiation

Journal of Extracellular Vesicles
Although cisplatin (CDDP) is widely employed in combination immunotherapy, no CDDP‐based regimen has shown a survival benefit when treating the ovarian cancers. This is mainly because the impact of CDDP on immunotherapy is not fully understood.
Liyan Zheng, Sijia Mu, Mingxue Liu, Panmin Lei, Jingchen Zhang, Yuting Dai, Chenxi He, Fengli Qu, Weihong Tan   +8 more
doaj   +1 more source

Immunohistochemical biomarker-associated radiomics for classifying thymic epithelial tumors: a multicenter retrospective study

npj Precision Oncology
The subtle imaging features of thymic epithelial tumors (TETs), which comprise multiple pathological subtypes of thymoma and thymic carcinoma, are of great significance for the identification of high-risk patients.
Yutian Zhang, Yangzhong Guo, Junyu Li, Haitao Jiang, Yueyu Huang, Bojian Feng, Wenhui Shen, You Xiao, Jiahui Wang, Chang Yu, Changchun Wang, Qiaoli Lv, An Zhao, Weimin Mao   +13 more
doaj   +1 more source

Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy

Molecular Cancer
Cellular senescence has gradually been recognized as a key process, which not only inhibits the occurrence of early tumors but also promotes advanced malignant progression through secretory and immunomodulatory functions.
Huiting Yang, Dong Liu, Liewang Qiu, Rui Wang, Chuchu Zhang, Danqing Yu, Qingping Zhong, Nitta Yuki, Zhentao Song, Taotao Zhu, Haixing Ju, Weifeng Hong, Ji Zhu   +12 more
doaj   +1 more source

Him is regulated by Tin to suppress cardiogenic cell fate.

, 2011
[[abstract]]The homeobox containing gene, tinman (tin) plays a pivotal role in heart development as well as cardiac function of Drosophila. Loss of tin function during embryogenesis, leads to the abolishment of heart precursor cells and the mature heart.
郭明偉, Ming-Wei Kuo
core  

Immune checkpoint inhibitors combined with chemotherapy in conversion therapy for stage IV gastric cancer: a multicenter retrospective cohort study

Cancer Immunology, Immunotherapy
Objectives To evaluate the efficacy of combining PD-1 inhibitors with chemotherapy in conversion therapy for patients with stage IV gastric cancer and to determine the populations most likely to benefit from this regimen.
Xingmao Huang, Xiangliu Chen, Jiahui Chen, Can Hu, Han Chen, Hang Chen, Jingquan Fang, Zeyao Ye, Yian Du, Pengfei Yu, Ling Huang   +10 more
doaj   +1 more source

Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation

Molecular Medicine
Background Whereas intestinal epithelial barrier dysfunction is implicated in inflammatory bowel disease (IBD), the underlying mechanisms remain elusive.
Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang   +7 more
doaj   +1 more source

The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors

Journal of Hematology & Oncology
Antibody-drug conjugates (ADCs) represent an important class of cancer therapies that have revolutionized the treatment paradigm of solid tumors.
Qing Wei, Peijing Li, Teng Yang, Jiayu Zhu, Lu Sun, Ziwen Zhang, Lu Wang, Xuefei Tian, Jiahui Chen, Can Hu, Junli Xue, Letao Ma, Takaya Shimura, Jianmin Fang, Jieer Ying, Peng Guo, Xiangdong Cheng   +16 more
doaj   +1 more source

New light on E.E. Cummings' drama, Him

, 1986
E. E. Cummings' avant-garde drama, Him (1927) is the subject of this study. As poet and painter, Cummings drew a picture of the play for the cover of the "sacrosanct" [his word) first edition. This picture is a unique psychological rebus-mandala.
Bast, Doreen Minsinger
core