Results 161 to 170 of about 78,402 (305)

Senescent Macrophages Promote Age‐Related Revascularization Impairment by Increasing Antiangiogenic VEGF‐A165B Expression

Aging Cell, EarlyView.
The underlying mechanisms of age‐related revascularization impairment are not clear. Our research firstly identified that macrophages were more senescent in the ischemic skeletal muscle of old mice and senescent macrophages could inhibit revascularization.
Minghong Chen, Junyu Chen, Yu Liu, Xuerui Wang, Meilian Yao, Jing Chen, Jian Zhang, Qun Huang   +7 more
wiley   +1 more source

Combined Effects of Mechanical Loading and Piezo1 Chemical Activation on 22‐Months‐Old Female Mouse Bone Adaptation

Aging Cell, EarlyView.
In vivo mechanical loading combined with Yoda2 injection produced an additive effect on cortical bone parameters in the tibiae of 22‐month‐old female mice. In vivo calcium signaling results suggest that Yoda2 could reach osteocytes and activate Piezo1.
Quentin A. Meslier, Robert Oehrlein, Sandra J. Shefelbine   +2 more
wiley   +1 more source

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Aging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair, Taylor Russo, Markus Riessland, Roger B. Sher   +3 more
wiley   +1 more source

Altered Relaxation and Mitochondria‐Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise

Aging Cell, EarlyView.
Slowed relaxation and altered MERCs embody early stages of aging in muscle, and are prevented by regular exercise. ABSTRACT Sarcopenia, or age‐related muscle dysfunction, contributes to morbidity and mortality. Besides decreases in muscle force, sarcopenia is associated with atrophy and fast‐to‐slow fiber type switching, which is typically secondary to
Ryan J. Allen, Ana Kronemberger, Qian Shi, R. Marshall Pope, Elizabeth Cuadra‐Muñoz, Wangkuk Son, Long‐Sheng Song, Ethan J. Anderson, Renata O. Pereira, Vitor A. Lira   +9 more
wiley   +1 more source

Head, withers and pelvic movement asymmetry and their relative timing in trot in racing Thoroughbreds in training [PDF]

, 2017
Bell, Dyson, Greve, Keegan, Keegan, Kelmer, Kramer, Maliye, Maliye, Maliye, Marshall, Persson-Sjodin, Pfau, Pfau, Pfau, Pfau, Pfau, Rhodin, Rhodin, Rungsri, Starke, Starke, Starke, Uhlir, Warner, Weishaupt, Weishaupt   +26 more
core   +1 more source

Prognostic factors in bushfire‐affected koalas–Kangaroo Island bushfire response 2020

Australian Veterinary Journal, EarlyView.
This study presents a retrospective analysis of clinical records data from koalas presenting for treatment following the large‐scale bushfire event on Kangaroo Island 2019–2020. The aim of the study was to identify prognostic factors for koalas affected by bushfire. Koalas (n = 199) were grouped based on their burn status in combination with their burn
O Funnell, J McLelland, A Kokosinska, T Stephenson, E Dunstan, B Turner, N Speight   +6 more
wiley   +1 more source

Suspected marsh mallow (Malva parviflora) toxicosis in ponies—Case cluster including an asymptomatic survivor

Australian Veterinary Journal, EarlyView.
There is limited published information on Malva parviflora toxicosis in horses. Four previously reported cases all resulted in death or euthanasia. The aim of this cluster investigation was to describe historical, clinical and clinicopathological findings of four ponies with suspected M.
J Bauquier, C Takahashi, C Rosales, J Pitt   +3 more
wiley   +1 more source

Acute onset neurological deficits and hypocalcaemia associated with nutritional secondary hyperparathyroidism in three juvenile servals (Leptailurus serval)

Australian Veterinary Journal, EarlyView.
Nutritional secondary hyperparathyroidism is a metabolic disorder caused by an imbalance in calcium homeostasis and is typically associated with the feeding of a calcium‐deficient diet. Nutritional secondary hyperparathyroidism has been reported in domestic species, including cats and dogs, as well as captive carnivores and wildlife including lions ...
JL Austen, JW Wheelahan, J O'Dwyer, S Beths, NL Rourke, BR Gardner   +5 more
wiley   +1 more source

Cerebellar defects are a primary pathology in mouse models of spinal muscular atrophy

Brain Pathology, EarlyView.
Purkinje cell (PC) degeneration is localized to posterior lobules in the cerebellum, and rescue of survival motor neuron protein expression levels in motor neurons does not ameliorate this effect. Representative images of sagittal cerebellar sections stained with anti‐calbindin in the vermis and hemisphere at P12 for wild type, ChATCre+ rescue (Rescue),
Nicholas C. Cottam, Morgan Dowling, Lingling Kong, Michelle Harran Chan‐Cortés, Christine J. Charvet, Naika Norzeron, Cameron Grover, Melissa A. Harrington, Charlotte J. Sumner, Jianli Sun   +9 more
wiley   +1 more source

Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation. [PDF]

Adv Sci (Weinh)
Li C, Shan Y, Zheng S, Tan P, Bai Y, Wang E, Xu L, Luo R, Chao S, Huang J, Ren P, Li Z, Feng H.   +12 more
europepmc   +1 more source