Results 161 to 170 of about 49,698 (296)

Proximal phalanges of digit 1 have different identities in the forelimbs and hindlimbs of the mouse. [PDF]

open access: yesSci Rep
Dang W   +8 more
europepmc   +1 more source

A Tale of Appendages: Investigating Limb and Tail Variation in Salamanders

open access: yesIntegrative Zoology, EarlyView.
We analyzed limb and tail proportions in 44% of known salamander species using a phylogenetic comparative approach. Our results revealed significant variation among families and ecological groups, with aquatic species showing longer limbs and basal lineages having shorter tails.
Giacomo Rosa   +4 more
wiley   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

open access: yesBrain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong   +8 more
wiley   +1 more source

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho   +5 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade   +7 more
wiley   +1 more source

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