Results 51 to 60 of about 566,882 (313)

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Outcomes of 1038 Hip Arthroscopies

Orthopaedic Journal of Sports Medicine, 2015
Objectives: The purpose of this study was to evaluate clinical outcomes, pain, and patient satisfaction following all hip arthroscopies performed by a single surgeon at a high volume referral center with a mean 2-year follow-up. Methods: During the study
Parth Lodhia MD, Tim Martin MA, Chengcheng Gui BSE, Christine E. Stake MA, S Pavan Vemula MA, Carlos Suarez-Ahedo MD, Sivashankar Chandrasekaran MD, Benjamin G. Domb MD   +7 more
doaj   +1 more source

Do Not Take for Granted! The Art of Elevating the Capsule in Hip Arthroscopy: A Stepwise Approach

Arthroscopy Techniques, 2019
Different techniques have been described to close or plicate the capsule. To perform these procedures, however, the capsule must be preserved, a consideration unfortunately often overlooked.
David R. Maldonado, M.D., Jeffrey W. Chen, B.A., Ajay C. Lall, MD, M.S., Cynthia Kyin, B.A., Rafael Walker-Santiago, M.D., Philip J. Rosinsky, M.D., Jacob Shapira, M.D., Benjamin G. Domb, M.D.   +7 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Maximal Outcome Improvement Willingness Thresholds Are Predictive of a Patient’s Willingness to Undergo the Same Surgery, in Retrospect, Given the Known Outcome of Their Primary Hip Arthroscopy

Arthroscopy, Sports Medicine, and Rehabilitation, 2022
Purpose: To determine the percent maximal outcome improvement willingness thresholds (MOWTs) for the Nonarthritic Hip Score (NAHS) and the visual analog scale (VAS) for pain that were associated with a patient’s willingness to undergo surgery, in ...
David R. Maldonado, M.D., James D. Fox, B.B.A., Cynthia Kyin, B.A., Andrew E. Jimenez, M.D., Benjamin R. Saks, M.D., Andrew J. Curley, M.D., Ajay C. Lall, M.D., M.S., Benjamin G. Domb, M.D.   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Microfracture in Hip Arthroscopy. Keep It Simple!

Arthroscopy Techniques, 2019
Despite all the advances in hip arthroscopy, microfracture is still the workhorse for treating focal and full-thickness cartilage lesions. The success of this treatment is owed to its reliability and simplicity.
David R. Maldonado, M.D., Jeffrey W. Chen, B.A., Ajay C. Lall, M.D., M.S., Cynthia Kyin, B.A., Rafael Walker-Santiago, M.D., Jacob Shapira, M.D., Philip J. Rosinsky, M.D., Benjamin G. Domb, M.D.   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

HIPs and HIP-reactive T cells [PDF]

Clinical and Experimental Immunology, 2019
Summary Mounting evidence implicates hybrid insulin peptides (HIPs) as important autoantigens in the development of type 1 diabetes (T1D). These fusion peptides formed between insulin and other pancreatic beta cell-derived peptides contain non-genomically encoded amino acid sequences, making them plausible targets for autoreactive T ...
T A Wiles, T Delong
openaire   +2 more sources

Femoral stem wear in cemented total hip replacement

, 2008
The great success of cemented total hip replacement to treat patients with end-stage osteoarthritis and osteonecrosis has been well documented. However, its long-term survivorship has been compromised by progressive development of aseptic loosening, and ...
Barrans, Simon, X-Q Jiang, Zhang, H. Y., Blunt, Liam, Jiang, Xiang, S Barrans, Zhao, Y., L Brown, Jiang, X. Q., Y Zhao, Blunt, L., L Blunt, Barrans, S., Brown, L., Zhang, Hongyu, H-Y Zhang, Brown, Leigh   +16 more
core   +1 more source