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Sugar defeats the Hippo: Glycogen regulation of the Hippo pathway in liver
Molecular Cell, 2021Liver glycogen is famous for glucose storage, but new work by Liu et al. (2021) now reveals that it's been hiding a few secrets and can directly promote liver enlargement and tumorigenesis by sequestering the tumor-suppressive Hippo signaling pathway.
Anh Thu, Nguyen-Lefebvre +2 more
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Immuno-hippo: Research progress of the hippo pathway in autoimmune disease
Immunology Letters, 2021Extensive research in Drosophila and mammals has identified the core components of Hippo signaling, which controls gene expression. Studies of Drosophila have demonstrated the highly conserved Hippo pathway controls tissue homeostasis and organ size by regulating the balance between cell proliferation and apoptosis.
Paipai, Guo +6 more
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Nature Reviews Molecular Cell Biology, 2007
How cell numbers are controlled during organ development is a problem that is still in need of answers. Recent studies in Drosophila melanogaster have delineated a novel signalling pathway, the Hippo pathway, which has an important role in restraining cell proliferation and promoting apoptosis in differentiating epithelial cells. Much like cancer cells,
Leslie J, Saucedo, Bruce A, Edgar
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How cell numbers are controlled during organ development is a problem that is still in need of answers. Recent studies in Drosophila melanogaster have delineated a novel signalling pathway, the Hippo pathway, which has an important role in restraining cell proliferation and promoting apoptosis in differentiating epithelial cells. Much like cancer cells,
Leslie J, Saucedo, Bruce A, Edgar
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The Hippo pathway and human cancer
Nature Reviews Cancer, 2013The Hippo pathway controls organ size in diverse species, whereas pathway deregulation can induce tumours in model organisms and occurs in a broad range of human carcinomas, including lung, colorectal, ovarian and liver cancer. Despite this, somatic or germline mutations in Hippo pathway genes are uncommon, with only the upstream pathway gene ...
Kieran F, Harvey +2 more
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Targeting the Hippo pathway in cancer
Nature Reviews Drug DiscoveryThe Hippo pathway is a highly conserved signalling network that controls tissue growth and cell fate, responding to physical properties of the tissue microenvironment and cell biological features such as adhesion and polarity. Hippo signalling perturbation is associated with several human diseases, particularly various solid cancers.
Kieran F. Harvey, Tracy T. Tang
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The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies
Journal of Cellular Physiology, 2020AbstractOsteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation of cellular functions.
Emel Rothzerg +5 more
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2013
The Hippo pathway is an established pathway that regulates apoptosis. The earliest characterisations of the mammalian MST1/2 kinases indicated that they were potent inducers of apoptosis in response to a wide range of stimuli. Elucidation of pathway components via genetic screens in Drosophila revealed that signalling through the Hippo pathway is ...
Garth Hamilton, Eric O’Neill
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The Hippo pathway is an established pathway that regulates apoptosis. The earliest characterisations of the mammalian MST1/2 kinases indicated that they were potent inducers of apoptosis in response to a wide range of stimuli. Elucidation of pathway components via genetic screens in Drosophila revealed that signalling through the Hippo pathway is ...
Garth Hamilton, Eric O’Neill
openaire +1 more source