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Modularity in the Hippo signaling pathway
Trends in Biochemical Sciences, 2010Metazoans have evolved several pathways to regulate the size of organs and ultimately that of organisms. One such pathway is known as Salvador-Warts-Hippo, or simply Hippo. Research on the Hippo pathway has grown exponentially during the past 8 years, revealing a complex signaling network.
Marius, Sudol, Kieran F, Harvey
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Sugar defeats the Hippo: Glycogen regulation of the Hippo pathway in liver
Molecular Cell, 2021Liver glycogen is famous for glucose storage, but new work by Liu et al. (2021) now reveals that it's been hiding a few secrets and can directly promote liver enlargement and tumorigenesis by sequestering the tumor-suppressive Hippo signaling pathway.
Anh Thu, Nguyen-Lefebvre +2 more
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The unfolding of the Hippo signaling pathway
Developmental Biology, 2022The development of a functional organ requires not only patterning mechanisms that confer proper identities to individual cells, but also growth-regulatory mechanisms that specify the final size of the organ. At the turn of the 21st century, comprehensive genetic screens in model organisms had successfully uncovered the major signaling pathways that ...
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Immuno-hippo: Research progress of the hippo pathway in autoimmune disease
Immunology Letters, 2021Extensive research in Drosophila and mammals has identified the core components of Hippo signaling, which controls gene expression. Studies of Drosophila have demonstrated the highly conserved Hippo pathway controls tissue homeostasis and organ size by regulating the balance between cell proliferation and apoptosis.
Paipai, Guo +6 more
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A mevalonate pathway–Hippo pathway connection
Nature Reviews Cancer, 2014Gemma K Alderton, Alderton Gemma K
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Targeting the Hippo pathway in cancer
Nature Reviews Drug DiscoveryThe Hippo pathway is a highly conserved signalling network that controls tissue growth and cell fate, responding to physical properties of the tissue microenvironment and cell biological features such as adhesion and polarity. Hippo signalling perturbation is associated with several human diseases, particularly various solid cancers.
Kieran F. Harvey, Tracy T. Tang
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The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies
Journal of Cellular Physiology, 2020AbstractOsteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation of cellular functions.
Emel Rothzerg +5 more
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2013
The Hippo pathway is an established pathway that regulates apoptosis. The earliest characterisations of the mammalian MST1/2 kinases indicated that they were potent inducers of apoptosis in response to a wide range of stimuli. Elucidation of pathway components via genetic screens in Drosophila revealed that signalling through the Hippo pathway is ...
Garth Hamilton, Eric O’Neill
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The Hippo pathway is an established pathway that regulates apoptosis. The earliest characterisations of the mammalian MST1/2 kinases indicated that they were potent inducers of apoptosis in response to a wide range of stimuli. Elucidation of pathway components via genetic screens in Drosophila revealed that signalling through the Hippo pathway is ...
Garth Hamilton, Eric O’Neill
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