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Nature Reviews Molecular Cell Biology, 2007
How cell numbers are controlled during organ development is a problem that is still in need of answers. Recent studies in Drosophila melanogaster have delineated a novel signalling pathway, the Hippo pathway, which has an important role in restraining cell proliferation and promoting apoptosis in differentiating epithelial cells. Much like cancer cells,
Leslie J, Saucedo, Bruce A, Edgar
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How cell numbers are controlled during organ development is a problem that is still in need of answers. Recent studies in Drosophila melanogaster have delineated a novel signalling pathway, the Hippo pathway, which has an important role in restraining cell proliferation and promoting apoptosis in differentiating epithelial cells. Much like cancer cells,
Leslie J, Saucedo, Bruce A, Edgar
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Multiphase coalescence mediates Hippo pathway activation
Cell, 2022The function of biomolecular condensates is often restricted by condensate dissolution. Whether condensates can be suppressed without condensate dissolution is unclear. Here, we show that upstream regulators of the Hippo signaling pathway form functionally antagonizing condensates, and their coalescence into a common phase provides a mode of ...
Li, Wang +12 more
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The Hippo pathway and human cancer
Nature Reviews Cancer, 2013The Hippo pathway controls organ size in diverse species, whereas pathway deregulation can induce tumours in model organisms and occurs in a broad range of human carcinomas, including lung, colorectal, ovarian and liver cancer. Despite this, somatic or germline mutations in Hippo pathway genes are uncommon, with only the upstream pathway gene ...
Kieran F, Harvey +2 more
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Modularity in the Hippo signaling pathway
Trends in Biochemical Sciences, 2010Metazoans have evolved several pathways to regulate the size of organs and ultimately that of organisms. One such pathway is known as Salvador-Warts-Hippo, or simply Hippo. Research on the Hippo pathway has grown exponentially during the past 8 years, revealing a complex signaling network.
Marius, Sudol, Kieran F, Harvey
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Immuno-hippo: Research progress of the hippo pathway in autoimmune disease
Immunology Letters, 2021Extensive research in Drosophila and mammals has identified the core components of Hippo signaling, which controls gene expression. Studies of Drosophila have demonstrated the highly conserved Hippo pathway controls tissue homeostasis and organ size by regulating the balance between cell proliferation and apoptosis.
Paipai, Guo +6 more
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Science's STKE, 2006
Three papers this week connect the atypical cadherin Fat to the Hippo signaling pathway (Hippo is a serine-threonine kinase that resembles the yeast Sterile-20 protein and acts as a tumor suppressor in Drosophila ), which is implicated in the control of tissue or organ size.
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Three papers this week connect the atypical cadherin Fat to the Hippo signaling pathway (Hippo is a serine-threonine kinase that resembles the yeast Sterile-20 protein and acts as a tumor suppressor in Drosophila ), which is implicated in the control of tissue or organ size.
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2013
The Hippo pathway is an established pathway that regulates apoptosis. The earliest characterisations of the mammalian MST1/2 kinases indicated that they were potent inducers of apoptosis in response to a wide range of stimuli. Elucidation of pathway components via genetic screens in Drosophila revealed that signalling through the Hippo pathway is ...
Garth Hamilton, Eric O’Neill
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The Hippo pathway is an established pathway that regulates apoptosis. The earliest characterisations of the mammalian MST1/2 kinases indicated that they were potent inducers of apoptosis in response to a wide range of stimuli. Elucidation of pathway components via genetic screens in Drosophila revealed that signalling through the Hippo pathway is ...
Garth Hamilton, Eric O’Neill
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Hippo Pathway Regulation by Tyrosine Kinases
2018The Hippo pathway utilizes a well-characterized Ser/Thr kinase cascade to control the downstream effectors, Yap and Taz. In addition, Yap/Taz and other Hippo pathway components are directly regulated by tyrosine kinases (TKs). The methodological strategies described here use the example of the c-Abl non-receptor TK and the Yap substrate to outline the ...
Nina, Reuven +2 more
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Hippo Pathway Regulation of Gastrointestinal Tissues
Annual Review of Physiology, 2015The Hippo pathway plays a crucial role in regulating tissue homeostasis and organ size, and its deregulation is frequently observed in human cancer. Yap is the major effector of and is inhibited by the Hippo pathway. In mouse model studies, inducible Yap expression in multiple tissues results in organ overgrowth.
Fa-Xing, Yu +3 more
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Energy stress tames the Hippo pathway
Nature Cell Biology, 2015The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.
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