Results 1 to 10 of about 41,599 (208)

Hippocampal Sclerosis: Causes and Prevention [PDF]

Seminars in Neurology, 2015
Hippocampal sclerosis is the commonest cause of drug-resistant epilepsy in adults, and is associated with alterations to structures and networks beyond the hippocampus.In addition to being a cause of epilepsy, the hippocampus is vulnerable to damage from seizure activity.
Matthew C Walker
exaly   +3 more sources

Hippocampal Malformations Do Not Necessarily Evolve into Hippocampal Sclerosis [PDF]

Epilepsia, 2005
Summary: Purpose:Hippocampal malformations have been proposed to underlie or evolve into hippocampal sclerosis, a common cause of refractory partial epilepsy. We report two patients with chronic epilepsy and developmental abnormalities of the hippocampus and cortex.
Arjune Sen, Maria Thom, Lillian Martinian   +2 more
exaly   +3 more sources

Longitudinal hippocampal atrophy in hippocampal sclerosis of aging

Aging Brain, 2023
Hippocampal sclerosis of aging (HS-A) is a common degenerative neuropathology in older individuals and is associated with dementia. HS-A is characterized by disproportionate hippocampal atrophy at autopsy but cannot be diagnosed during life. Therefore, little is known about the onset and progression of hippocampal atrophy in individuals with HS-A.
Li, Janice X, Nguyen, Hannah L, Qian, Tianchen, Woodworth, Davis C, Sajjadi, S Ahmad, Initiative, for the Alzheimer's Disease Neuroimaging   +5 more
openaire   +5 more sources

Deregulation of cdk5 in Hippocampal Sclerosis [PDF]

Journal of Neuropathology and Experimental Neurology, 2006
Hippocampal sclerosis (HS) is the most common cause of chronic medically refractory epilepsy in adults. Histologically, HS is characterized by segmental neuronal loss and gliosis. Although neuronal loss is important to the pathophysiology of HS, the molecular mechanisms underlying the neuronal loss remain uncertain.
Sen, A, Thom, M, Martinian, L, Jacobs, T, Nikolic, M, Sisodiya, S   +5 more
openaire   +3 more sources

Hippocampal sclerosis dementia: a reappraisal [PDF]

Acta Neuropathologica, 2007
Hippocampal sclerosis (HpScl) is characterized by neuronal loss and gliosis in CA1 and subiculum of the hippocampus, and may be one contributing factor to dementia in old age. The term hippocampal sclerosis dementia (HpSclD) designates the presence of both hippocampal sclerotic lesions and a dementia syndrome.
Probst A, Taylor KI, Tolnay M
openaire   +3 more sources

Cardiovascular Regulation and Hippocampal Sclerosis [PDF]

Epilepsia, 2004
Summary: Purpose:Cardiovascular dysregulation has been detected in patients with temporal lobe epilepsy (TLE) by using cardiovascular reflex tests and analysis of heart rate variability (HRV). The two methods have not previously been used in the same study to compare them in the assessment of cardioregulatory function.
Hanna, Ansakorpi, Juha T, Korpelainen, Päivikki, Tanskanen, Heikki V, Huikuri, Antero, Koivula, Uolevi, Tolonen, Juhani, Pyhtinen, Vilho V, Myllylä, Jouko I T, Isojärvi   +8 more
openaire   +2 more sources

Corpora amylacea in hippocampal sclerosis [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1997
Corpora amylacea have been reported in around 60% of hippocampal sclerosis specimens. The aim was to determine whether there are clinical and quantitative hippocampal MRI differences between hippocampal sclerosis with and without corpora amylacea. Corpora amylacea density was determined in 46 resected hippocampi of patients with temporal lobe epilepsy,
W, Van Paesschen, T, Revesz, J S, Duncan
openaire   +2 more sources

Texture Analysis of Hippocampal Sclerosis [PDF]

Epilepsia, 2003
Summary:  Mesial temporal lobe epilepsy (MTLE) is frequently associated with refractory seizures and pathologic features of hippocampal sclerosis (HS). Quantitative magnetic resonance imaging (MRI) techniques can improve the detection and quantification of HS.
Leonardo, Bonilha, Eliane, Kobayashi, Gabriela, Castellano, Giselle, Coelho, Eduardo, Tinois, Fernando, Cendes, Li M, Li   +6 more
openaire   +2 more sources

Cytoarchitectural Abnormalities in Hippocampal Sclerosis [PDF]

Journal of Neuropathology & Experimental Neurology, 2002
Hippocampal sclerosis (HS) is the most common pathological substrate for temporal lobe epilepsy with a characteristic pattern of loss of principle neurons primarily in CA1 and hilar subfields. Other cytoarchitectural abnormalities have been identified in human HS specimens, including dispersion of dentate granule cells and cytoskeletal abnormalities in
Maria, Thom, Sanjay M, Sisodiya, Andrew, Beckett, Lillian, Martinian, Woan-Ru, Lin, William, Harkness, Tejal N, Mitchell, John, Craig, John, Duncan, Francesco, Scaravilli   +9 more
openaire   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source