Results 91 to 100 of about 511,468 (345)

Observations on the relationship between verbal explicit and implicit memory and neuronal density in the left and right hippocampus in temporal lobectomy patients. [PDF]

, 1998
The relationship between neuronal density and verbal memory in left and right hippocampal subfields was investigated in patients who underwent surgery for alleviation of temporal lobe epilepsy.
Beardsworth, Elizabeth, Esiri, Margaret, Zaidel, Dahlia W.   +2 more
core  

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Hippocampal Abnormalities with Cortical Malformations in Epilepsy Patients

Pediatric Neurology Briefs, 2010
The occurrence of various types and MRI appearance of hippocampal abnormalities in 220 patients with malformations of cortical development (MCD) were studied in various centers and large public hospital outpatient clinics in Germany and Austria.
J Gordon Millichap
doaj   +1 more source

Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography [PDF]

, 2009
Anterior temporal lobe resection is often complicated by superior quadrantic visual field deficits (VFDs). In some cases this can be severe enough to prohibit driving, even if a patient is free of seizures.
A. W. McEvoy, Alexander, Babb, Basser, Bassi, Behrens, Chen, Ciccarelli, Cook, Curcio, D. C. Alexander, Duncan, Ebeling, Egan, FALCONER, Fris  n, G. J. M. Parker, HARVEY, Hughes, J. Acheson, J. S. Duncan, Kamada, Kier, Kirkham, Krolak-Salmon, M. Cercignani, M. J. Koepp, M. R. Symms, M. Yogarajah, Manji, Marino, Mori, N. K. Focke, Nilsson, Nilsson, Oldfield, Parker, Penfield, Powell, Ray, S. Bonelli, Semah, Spalding, Tecoma, Wiebe, Woermann, Yamada, Yamamoto, Yasargil   +48 more
core   +3 more sources

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Global Hippocampal Volume Reductions and Local CA1 Shape Deformations in Amyotrophic Lateral Sclerosis

Frontiers in Neurology, 2018
There is increasing evidence for hippocampal involvement in Amyotrophic Lateral Sclerosis (ALS). Recent neuroimaging studies have been focused on disease-related hippocampal volume alterations while changes in hippocampal shape have been investigated ...
Judith Machts, Judith Machts, Stefan Vielhaber, Stefan Vielhaber, Katja Kollewe, Susanne Petri, Joern Kaufmann, Mircea Ariel Schoenfeld, Mircea Ariel Schoenfeld, Mircea Ariel Schoenfeld   +9 more
doaj   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Congenital Porencephaly and Hippocampal Sclerosis

Pediatric Neurology Briefs, 1997
MRI volumetric findings were correlated with seizure patterns and EEGs in 14 patients with intractable seizures, porencephaly and hippocampal sclerosis (HS) in a study at the University of Alabama, Birmingham, AL.
J Gordon Millichap
doaj   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

Advanced Science, EarlyView.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li, Fulong Man, Jianwei Cheng, Li Chen, Yongyong Li, Haiqing Dong   +5 more
wiley   +1 more source