Results 91 to 100 of about 41,599 (208)

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

Brain Pathology, EarlyView.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson   +10 more
wiley   +1 more source

Automatic detection of hippocampal sclerosis in patients with epilepsy. [PDF]

Epilepsia
Belke M, Zahnert F, Steinbrenner M, Halimeh M, Miron G, Tsalouchidou PE, Linka L, Keil B, Jansen A, Möschl V, Kemmling A, Nimsky C, Rosenow F, Menzler K, Knake S.   +14 more
europepmc   +1 more source

Response: Hippocampal Sclerosis [PDF]

Epilepsia, 2004
Adrian Lowe, Christine Kilpatrick, Terence J. O'Brien   +2 more
openaire   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Identification of epileptic hippocampal sclerosis related genes through bulk and single-nucleus RNA sequencing datasets. [PDF]

Cell Mol Life Sci
Wang J, Zhou Z, Wu D, Zeng Y, Huang H, Zhou Q, Meng F.   +6 more
europepmc   +1 more source

SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism

Cell Proliferation, EarlyView.
This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang   +5 more
wiley   +1 more source

Glymphatic system dysfunction in temporal lobe epilepsy with hippocampal sclerosis: MRI-based evaluation of circulatory markers and disease progression. [PDF]

Front Neurosci
Kuang Y, Hu D, Chu H, Zhang R, Diao Z, Wang K, Yue X, Chen Y, Qiu S, An J.   +9 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Ablation of Unilateral Hippocampal GABAergic Neurons: A Novel Mouse Model of Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis. [PDF]

CNS Neurosci Ther
Tang T, Xu J, Fu B, Geng C, Li Y, Qi Y, Hou C, He J, Wang Y, Luo Y, Zhao G.   +10 more
europepmc   +1 more source

Neural correlates of pure apathy in multiple sclerosis: An exploratory neuroimaging study

Journal of Neuropsychology, EarlyView.
Abstract Pure apathy is relatively common in people with Multiple Sclerosis (PwMS), but its neural mechanisms remain unexplored. Therefore, we investigated the neural correlates of pure apathy in PwMS, differentiating it from depression. Sixty‐two PwMS underwent neuropsychological assessments and Magnetic Resonance Imaging scans.
Valentina Torchia, Vera Gramigna, Mariachiara Gaita, Daniele Spitaleri, Antonio Costanzo, Liana Palermo, Florindo d'Onofrio, Simona Raimo   +7 more
wiley   +1 more source