Results 191 to 200 of about 511,468 (345)

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

In severe ADNC, hippocampi with comorbid LATE-NC and hippocampal sclerosis have substantially more astrocytosis than those with LATE-NC or hippocampal sclerosis alone. [PDF]

J Neuropathol Exp Neurol, 2023
Niedowicz DM, Katsumata Y, Nelson PT.
europepmc   +1 more source

Doublecortin (DCX) immunoreactivity in hippocampus of chronic refractory temporal lobe epilepsy patients with hippocampal sclerosis [PDF]

, 2010
Luciana D’Alessio, Héctor Konopka, Ester Marı́a López, Eduardo Seoane, D. Consalvo, Silvia Oddo, Silvia Kochen, Juan José López‐Costa   +7 more
openalex   +1 more source

European Society for the Study of Coeliac Disease 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 1: Diagnostic Approach

United European Gastroenterology Journal, EarlyView.
Infographic. This infographic summarizes the diagnostic approach to CeD in adults, including initial serological testing, histological confirmation, criteria for a no‐biopsy diagnosis, seronegative CeD, potential CeD, and the role of gluten challenge. Source: Authors' own creation (based on current clinical guidelines).
Abdulbaqi Al‐Toma, Fabiana Zingone, Federica Branchi, Annalisa Schiepatti, Georgia Malamut, Cristina Canova, Isabella Rosato, Honoria Ocagli, Nick Trott, Luca Elli, Alina Popp, Carmen Gianfrani, Renata Auricchio, Andra Neefjes‐Borst, David S. Sanders, Christophe Cellier, Chris J. Mulder, Gerd Bouma, Knut E. A. Lundin, Ludvig M. Sollid, Michael Schumann   +20 more
wiley   +1 more source

Twins with temporal lobe epilepsy: genetic contributions to hippocampal sclerosis and other subtypes. [PDF]

Brain
Dang YL, Esnault K, Fitt G, O'Brien TJ, Jackson GD, Perucca P, Berkovic SF.   +6 more
europepmc   +1 more source

Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis

Robert Carton, Michael G. Doyle, Hugh Kearney, Charles A. Steward, Nicholas Lench, Anthony S. Rogers, Erin L. Heinzen, Seamus McDonald, Joanna Fay, L.G. Austin, Alan Beausang, Jane Cryan, Francesca Brett, Hany El‐Naggar, Peter Widdess‐Walsh, Daniel J. Costello, Ronan Kilbride, Colin P. Doherty, Kieron J. Sweeney, Donncha F. O’Brien, David C. Henshall, Norman Delanty, Gianpiero L. Cavalleri, Katherine A. Benson   +23 more
openalex   +1 more source

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study

Lancet Neurology, 2018
Hyun-Sik Yang, Lei Yu, Charles C. White, L. Chibnik, J. Chhatwal, R. Sperling, D. Bennett, J. Schneider, P. D. Jager   +8 more
semanticscholar   +1 more source

1275‐nm Photobiomodulation Alleviates Brain Drainage Impairment as a Promising Therapeutic Strategy for Aging‐Related Neurological Decline

Aging Cell, EarlyView.
Noninvasive 1275‐nm photobiomodulation improves brain drainage and promotes lymphatic clearance of advanced glycation end products (AGEs) in an aging model (AM) in male mice. These effects are associated with nitric oxide release‐mediated dilation of meningeal lymphatic vessels (MLVs).
Hao Lin, Shaojun Liu, Qihang Yang, Junming Li, Jue Wang, Oxana Semyachkina‐Glushkovskaya, Dongyu Li, Tingting Yu, Dan Zhu   +8 more
wiley   +1 more source

Automatic detection of hippocampal sclerosis in patients with epilepsy. [PDF]

Epilepsia
Belke M, Zahnert F, Steinbrenner M, Halimeh M, Miron G, Tsalouchidou PE, Linka L, Keil B, Jansen A, Möschl V, Kemmling A, Nimsky C, Rosenow F, Menzler K, Knake S.   +14 more
europepmc   +1 more source

Age‐Related Alterations in Hippocampal Microstructure Quantified Using High‐Gradient Diffusion MRI (dMRI) in an Unfolded Hippocampal Space

Aging Cell, EarlyView.
Using high‐gradient diffusion MRI with the SANDI model and HippUnfold for fine‐scale analysis, we detected localized hippocampal aging changes beyond volumetric/thickness reductions. Subiculum and dentate gyrus exhibit significantly reduced soma density/size and increased extracellular space, highlighting subtle microstructural alterations critical for
Yixin Ma, Hansol Lee, Kwok‐Shing Chan, Laleh Eskandarian, Kyla Gaudet, Qiyuan Tian, Aneri Bhatt, Julianna Gerold, Andrew W. Russo, David H. Salat, Eric C. Klawiter, Susie Y. Huang, Hong‐Hsi Lee   +12 more
wiley   +1 more source