Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]
, 2018 We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe +12 more
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Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination [PDF]
, 2012 New CNS neurons and glia are generated throughout adulthood from endogenous neural stem and progenitor cells. These progenitors can respond to injury, but their ability to proliferate, migrate, differentiate, and survive is usually insufficient to ...
Deverman, Benjamin E. +1 more
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Detection of partial loss of hippocampal striation at 1.5 Tesla magnetic resonance imaging
Insights into Imaging, 2019 Objectives Partial loss of hippocampal striation (PLHS) is recently described in 3 T and 7 T MR imaging as a sensitive indicator of hippocampal sclerosis.
Anitha Sen, Sudhakaran Sankaran
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Magnetic Resonance Spectroscopy in Temporal Lobe Epilepsy [PDF]
International Journal of Anatomy Radiology and Surgery, 2017 Introduction: Epilepsy affects 2% to 5% of the population at some time in their lives and hippocampal sclerosis accounts for 50% to 70% of cases.
Siddharth Prakash +3 more
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Cytoarchitectural Abnormalities in Hippocampal Sclerosis [PDF]
Journal of Neuropathology & Experimental Neurology, 2002 Hippocampal sclerosis (HS) is the most common pathological substrate for temporal lobe epilepsy with a characteristic pattern of loss of principle neurons primarily in CA1 and hilar subfields. Other cytoarchitectural abnormalities have been identified in human HS specimens, including dispersion of dentate granule cells and cytoskeletal abnormalities in
Maria, Thom +9 more
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Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease [PDF]
, 2010 The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail.
Bartley, Máiréad +12 more
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Answer and discussion paediatric neuroimaging quiz case
South African Journal of Radiology, 2016 A three-and-a-half-year-old male child was referred for neuroimaging under general anaesthesia for intractable seizures. A final diagnosis of probable tuberous sclerosis with associated left hippocampal sclerosis was made.
Shalendra Misser
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Texture Analysis of Hippocampal Sclerosis [PDF]
Epilepsia, 2003 Summary: Mesial temporal lobe epilepsy (MTLE) is frequently associated with refractory seizures and pathologic features of hippocampal sclerosis (HS). Quantitative magnetic resonance imaging (MRI) techniques can improve the detection and quantification of HS.
Leonardo, Bonilha +6 more
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Automated hippocampal segmentation in patients with epilepsy: Available free online [PDF]
, 2013 Hippocampal sclerosis, a common cause of refractory focal epilepsy, requires hippocampal volumetry for accurate diagnosis and surgical planning. Manual segmentation is time-consuming and subject to interrater/intrarater variability.
Bartlett, PA +8 more
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Early Seizures and Hippocampal Pathology
Pediatric Neurology Briefs, 1996 The relation of childhood seizures to hippocampal neuron loss, mossy fiber synaptic reorganization, and eventual hippocampal sclerosis was investigated at the Brain Research Institute, University of California, Los Angeles, and the Cleveland Clinic ...
J Gordon Millichap
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