Results 211 to 220 of about 633,597 (336)

α-Methyltryptophan mitigates cognitive impairment in db/db mice: involvement of gut-brain metabolic remodeling. [PDF]

open access: yesNutr Metab (Lond)
Cai A   +10 more
europepmc   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao   +12 more
wiley   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

open access: yesAdvanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li   +10 more
wiley   +1 more source

Presynaptic inhibitory effect of acetylcholine in the hippocampus [PDF]

open access: hybrid, 1981
Rita J. Valentino, Raymond Dingledine
openalex   +1 more source

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

open access: yesAdvanced Science, EarlyView.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano   +11 more
wiley   +1 more source

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