Results 281 to 290 of about 633,597 (336)

E-2001, a novel anti-ischemic agent (2): Protective effect on ischemic neuronal damage in the gerbil hippocampus

open access: gold, 1988
Takahiro Nakazawa   +5 more
openalex   +1 more source

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

open access: yesCytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński   +2 more
wiley   +1 more source

LdIL-2 treatment in ASD: a novel immunotherapeutic approach targeting Th/Treg dysfunction and neuroinflammation. [PDF]

open access: yesTransl Psychiatry
Li M   +16 more
europepmc   +1 more source

Derivatization of Small Molecules using Deuterated Analog of Reactive Matrix to Facilitate Identification in Mass Spectrometry Imaging

open access: yesChemistry–Methods, EarlyView.
The deuterated FMP‐10 analog, FMP‐10‐d3, enhances identification through isotopic labeling, providing structural insights via unique mass shifts. The approach improves the analysis of neurotransmitters and metabolites, facilitating neurochemical mapping and spatial metabolomics, with applications in neurodegenerative disease research. Mass spectrometry
Theodosia Vallianatou   +7 more
wiley   +1 more source

Hippocampal mismatch signals are based on episodic memories and not schematic knowledge. [PDF]

open access: yesProc Natl Acad Sci U S A
Varga DK   +4 more
europepmc   +1 more source

Amygdala-hippocampus connectivity and childhood depressive symptoms: subnuclei insights and self-concept roles. [PDF]

open access: yesTransl Psychiatry
Luo L   +9 more
europepmc   +1 more source

Safety and Efficacy of the NMDA‐2b‐Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre   +9 more
wiley   +1 more source

Disruption of ClC-3-mediated 2Cl<sup>-</sup>/H<sup>+</sup> exchange leads to behavioural deficits and thalamic atrophy. [PDF]

open access: yesSci Rep
Balduin C   +14 more
europepmc   +1 more source

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina   +12 more
wiley   +1 more source

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