Nutraceutical Potential in Disease Mitigation and Health Enhancement of Actinidia spp. (Kiwifruit) ABSTRACT This review offers an in‐depth exploration of the Actinidia species (kiwifruit) nutritional composition, the pivotal role of its primary bioactive compounds, and their potential applications across the aforementioned health concerns. Furthermore,
Allah Rakha+7 more
wiley +1 more source
Attenuated PINK1 autophosphorylation play neuroprotective and anti-seizure roles in neonatal hypoxia. [PDF]
Yuan Y+10 more
europepmc +1 more source
Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine
Astroglial CB1R mediates long‐term synaptic plasticity (LTD) in the Nucleus accumbens. Amphetamine saturates adenosine receptors and blocks LTD in males, but not females. Locomotor effects of amphetamine require astroglial CB1R in males, but not in females.
Yamuna Mariani+15 more
wiley +1 more source
Effects of m<sup>6</sup>A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ<sub>1-42</sub> in 5 × FAD mice. [PDF]
Chen H+11 more
europepmc +1 more source
An interview with Ondřej Strýček, 2025 Epilepsia Open prize winner for clinical research
Epilepsia Open, EarlyView.
Merab Kokaia, Piero Perucca
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In a pre‐symptomatic mouse model of Alzheimer disease, despite higher amyloid‐β load, females display fewer plaques than males. More efficient synaptic transmission as well as less microgliosis point to better early coping with pathogenesis in females.
Thomas Chaigneau+7 more
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TREM2 deficiency exacerbates cognitive impairment by aggravating α-Synuclein-induced lysosomal dysfunction in Parkinson's disease. [PDF]
Zhu B+14 more
europepmc +1 more source
Oligodendrogenesis in Evolution, Development and Adulthood
Oligodendrocytes and myelin took shape in jawed vertebrates. During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin. Adaptive myelination, which fine‐tunes neural circuits in response to neuronal
Hao Hu+3 more
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The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles. [PDF]
Xie J+6 more
europepmc +1 more source
The glial Na+ pump regulates [K+]o during neuronal activity, and the neuronal version restores [K+]o to baseline. Spreading depression‐related rise of K+ does not cause SD propagation via suppression of Na+/K+‐ATPase or glutamate transport. ABSTRACT Neuronal activity in the central nervous system is associated with a [K+]o transient that is swiftly ...
Brian Skriver Nielsen+6 more
wiley +1 more source