Results 31 to 40 of about 24,751 (213)
Prediction, sequences and the hippocampus [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2009 Recordings of rat hippocampal place cells have provided information about how the hippocampus retrieves memory sequences. One line of evidence has to do with phase precession, a process organized by theta and gamma oscillations. This precession can be interpreted as the cued prediction of the sequence of upcoming positions.
John, Lisman, A D, Redish
openaire +2 more sources
Diffusion MRI of the Hippocampus
The Journal of Neuroscience, 2023 The hippocampus is a brain structure that plays key roles in a variety of cognitive processes. Critically, a wide range of neurological disorders are associated with degeneration of the hippocampal microstructure, defined as neurons, dendrites, glial cells, and more.
Bradley G. Karat +2 more
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Symptomatic remission and hippocampus volume in schizophrenia
Psychiatry and Clinical Psychopharmacology, 2021 Objective: A recent meta-analysis of brain structure studies in schizophrenia has demonstrated that the most commonly reported deficit in brain regions was in left medial temporal lobe, which contains the hippocampus.
Ping Tsun Chang +2 more
doaj
Frontiers in Molecular Neuroscience, 2017 The dorsal and ventral regions of the hippocampus are important in cognitive and emotional processing, respectively. Various approaches have revealed the differential molecular and structural characteristics, and functional roles of the hippocampus ...
A-Ram Lee +8 more
doaj +1 more source
Neuropsychopharmacology Reports, 2021 Aims Dietary Mg2+ deficiency (MgD) impairs hippocampus‐dependent memory in mice; however, the molecular mechanisms underlying MgD‐induced memory impairments are unclear.
Ryuhei Tsuji +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
Hormones and the hippocampus [PDF]
Journal of Endocrinology, 2001 Abstract Hippocampal lesions produce memory deficits, but the exact function of the hippocampus remains obscure. Evidence is presented that its role in memory may be ancillary to physiological regulation. Molecular studies demonstrate that the hippocampus is a primary target for ligands that reflect body physiology, including ion ...
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source