Results 81 to 90 of about 633,597 (336)

Medial temporal lobe contributions to intra-item associative recognition memory in the aging brain [PDF]

, 2014
Aging is associated with a decline in episodic memory function. This is accompanied by degradation of and functional changes in the medial temporal lobe (MTL) which subserves mnemonic processing.
John Russel Hodges, John Russel Hodges, John Russel Hodges, Marshall Axel Dalton, Marshall Axel Dalton, Marshall Axel Dalton, Michael eHornberger, Michael eHornberger, Michael eHornberger, Olivier ePiguet, Olivier ePiguet, Olivier ePiguet, Sicong eTu, Sicong eTu, Sicong eTu   +14 more
core   +2 more sources

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

The hippocampus dissociates present from past and future goals

Nature Communications
Our brain adeptly navigates goals across time frames, distinguishing between urgent needs and those of the past or future. The hippocampus is a region known for supporting mental time travel and organizing information along its longitudinal axis ...
Alison Montagrin, Denise E. Croote, Maria Giulia Preti, Liron Lerman, Mark G. Baxter, Daniela Schiller   +5 more
doaj   +1 more source

Hydrogen Sulfide Prevents LPS-Induced Depression-like Behavior through the Suppression of NLRP3 Inflammasome and Pyroptosis and the Improvement of Mitochondrial Function in the Hippocampus of Mice

Biology, 2023
Hydrogen sulfide (H2S) has been implicated to have antidepressive effects. We sought to investigate the prevention effects of H2S donor NaHS on depression-like behavior induced by lipopolysaccharide (LPS) in mice and its potential mechanisms.
Peng Bao, Yuxiang Gong, Yanjie Wang, Miaomiao Xu, Zhenyu Qian, Xin Ni, Jianqiang Lu   +6 more
doaj   +1 more source

Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]

, 2018
We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe, Colamartino, Marco, Di Menna, Luisa, Fiori, Elena, Iacovelli, Luisa, Leuzzi, Vincenzo, Nardecchia, Francesca, Nicoletti, Ferdinando, Nistico, Robert, Orlando, Rosamaria, Pascucci, Tiziana, Piccinin, Sonia, Puglisi-Allegra, Stefano   +12 more
core   +2 more sources

Genomic Anatomy of the Hippocampus [PDF]

Neuron, 2008
Availability of genome-scale in situ hybridization data allows systematic analysis of genetic neuroanatomical architecture. Within the hippocampus, electrophysiology and lesion and imaging studies demonstrate functional heterogeneity along the septotemporal axis, although precise underlying circuitry and molecular substrates remain uncharacterized ...
Susan M. Sunkin, Vladimir B. Bajic, Carol L. Thompson, Allison Cusick, Amy Bernard, Ralph B. Puchalski, Zackery L. Riley, Allan R. Jones, Sayan Dev Pathak, Ed S. Lein, Marty Mortrud, Andreas Jeromin, Lydia Ng, Cameron Ross MacPherson, Michael Hawrylycz, Fred H. Gage   +15 more
openaire   +3 more sources

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity. [PDF]

, 2015
The superficial layers of the medial entorhinal cortex (MEC) are a major input to the hippocampus. The high proportion of spatially modulated cells, including grid cells and border cells, in these layers suggests that MEC inputs are critical for the ...
Boublil, Brittney L, Brandon, Mark P, Cannova, Christopher C, Hales, Jena B, Leibold, Christian, Leutgeb, Jill K, Leutgeb, Stefan, Mankin, Emily A, Schlesiger, Magdalene I   +8 more
core  

Dedicated hippocampal inhibitory networks for locomotion and immobility [PDF]

, 2017
Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized.
Arriaga, Moises, Han, Edward B
core   +2 more sources