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Hirschsprung’s Disease—Recent Understanding of Embryonic Aspects, Etiopathogenesis and Future Treatment Avenues

Medicina, 2020
Hirschsprung’s disease is a neurocristopathy, caused by defective migration, proliferation, differentiation and survival of neural crest cells, leading to gut aganglionosis. It usually manifests rapidly after birth, affecting 1 in 5000 live births around
Martin Klein, Ivan Varga
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Hirschsprung's disease [PDF]

Seminars in Pediatric Surgery, 2010
Hirschsprung's disease (HSCR) is characterized by absence of the enteric nervous system in a variable portion of the distal gut. Affected infants usually present in the days after birth with bowel obstruction.
GarciaBarcelo, M, Kenny, SE, Tam, PKH
core   +5 more sources

Early presentation of Hirschsprung’s disease with initial meconium passage: A diagnostic challenge [PDF]

SAGE Open Medical Case Reports
Hirschsprung’s disease is a congenital condition characterized by an absence of enteric ganglionic cells. In this paper, we report a case of an 8-day-old male infant presenting with a history of constipation and progressive abdominal distension. Meconium
Tuba Chaudry, Susan Flesher
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Advance in susceptibility genes and epigenetic regulation in Hirschsprung's disease [PDF]

Jichu yixue yu linchuang, 2023
Hirschsprung's disease(HSCR)is a disease resulted from abnormal enteric nervous system development. The abnormal coding of related genes may affect the migration, proliferation, differentiation or survival of neural crest cells in digestive tract and ...
WANG Taiyao, ZHENG Lifei
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Treatment of postoperative intestinal dysfunction of hirschsprung's disease based on the principle of “anorectal balance”

Frontiers in Surgery, 2022
PurposeRadical surgery is the most effective treatment for Hirschsprung's disease. However, some children still have symptoms of intestinal dysfunction such as constipation, abdominal distension, and recurrent enterocolitis after operation.
Li Tian, Li Tian, Chensen Ma, Chensen Ma, Zhengdong Deng, Zhengdong Deng, Tianqi Zhu, Tianqi Zhu, Xiang Zhao, Xiang Zhao, Ying He, Ying He, Mingfa Wei, Mingfa Wei, Jiexiong Feng, Jiexiong Feng, Donghai Yu, Donghai Yu   +17 more
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The Classification and Surgical Treatments in Adult Hirschsprung’s Disease: A Retrospective Study

Frontiers in Medicine, 2022
PurposeTo explore the treatments and short-term effects of different types of adult Hirschsprung’s disease.Methods89 patients treated in Shanghai Changhai Hospital were retrospectively analyzed.
Shengzhe Ma, Yue Yu, Anfu Pan, Haifeng Gong, Zheng Lou, Lianjie Liu, Liqiang Hao, Ronggui Meng, Jinke Sui, Wei Zhang   +9 more
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Enteric Neurospheres Are Not Specific to Neural Crest Cultures: Implications for Neural Stem Cell Therapies [PDF]

, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
A Barlow, A Pini Prato, A Zani, AG Baynash, AG Catto-Smith, AJ Burns, AJ Burns, Alan J. Burns, AS Wallace, C Caldwell, C Kalcheim, C Laranjeira, CH Knowles, Conor McCann, D Natarajan, Dipa Natarajan, DM Rodrigues, E Panza, Ellen Binder, GE Boeckxstaens, H Tsuji, HM Pallari, J Amiel, Jean-Marie Delalande, Julie Cooper, L Becker, L Ludman, M Hanani, M Metzger, Mara Cananzi, MC Nunes, MD Gershon, Mirella Dottori, MP Sanchez, MT Liu, N Bondurand, N Nagoshi, N Thapar, Nikhil Thapar, NR Druckenbrod, PS Danielian, R Hotta, R Hotta, R Zufferey, Rania Kronfli, RC Mifflin, RM Lindley, S Almond, S Bixby, S Hetz, S Srinivas, S Theocharatos, SJ Conway, SJ Howe, SJ McKeown, TA Heanue, TP Rothman, U Rauch, V Sasselli, X Jiang, Y Matsuda, YH Tsai   +61 more
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Adult Hirschsprung’s disease presenting as chronic constipation: a case report

Journal of Medical Case Reports, 2023
Background Hirschsprung’s disease is a congenital disorder identified by the absence of ganglion cells at the Meissner’s plexus of the submucosa and Auerbach’s plexus of the muscularis. This disease can be found in approximately 1 in 5000 live births. It
Theresia Monica Rahardjo, Yeppy Arief Nurzaman, Janice Natalia, Indra Hapdijaya, Livia Devina, Hendrik Andrianto, Jeffrey Christian Mahardhika   +6 more
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Hirschsprung's Disease - Review of Clinical Features, Diagnosis and Treatment

Journal of Education, Health and Sport, 2023
Introduction and purpose: Hirschsprung's disease, also known as congenital aganglionic megacolon, is a rare congenital disorder that affects the large intestine.
Rafał Tkaczyk, Gabriela Świątek, Jakub Tomczyk, Weronika Sosnowska, Maria Tomkiewicz, Kalina Taracha, Maciej Tomkiewicz, Aleksandra Brzozowska, Kornelia Trusz, Iwona Wanat   +9 more
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Familial Experience With Hirschsprung's Disease Improves the Patient's Ability to Cope

Frontiers in Pediatrics, 2022
IntroductionFamilial occurrence of Hirschsprung's disease may have a positive effect on patients' ability to cope with the disease. The aim was to compare long-term bowel function and generic quality of life between patients with familial and non ...
Sanne J. Verkuijl, Sanne J. Verkuijl, Rob J. Meinds, Rob J. Meinds, Alida F. W. van der Steeg, Cornelius E. J. Sloots, Ernst van Heurn, Ivo de Blaauw, Wim G. van Gemert, Marieke J. Witvliet, Karin M. Vermeulen, Monika Trzpis, Paul M. A. Broens, Paul M. A. Broens   +13 more
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