Results 11 to 20 of about 4,848,621 (165)

Anorectal malformation and Hirschsprung disease in an otherwise healthy infant [PDF]

Journal of Pediatric Surgery Case Reports, 2022
Background: Hirschsprung disease and anorectal malformations are two conditions that are rarely associated with one another. Current reports of anorectal malformations with concurrent Hirschsprung disease predominantly describe children with genetic ...
Audra Rougraff, Britney L. Grayson, Alan P. Ladd   +2 more
doaj   +2 more sources

Investigation of The Histopathological and Histometric Changes in Rectum Tissue Biopsies of Hirschsprung and Non-Hirschsprung Disease in Neonate and Infant [PDF]

Al-Mustansiriyah Journal of Science, 2023
Hirschsprung disease is one of the most common and problematic infancy and childhood maladies. The most reliable method for diagnosis is the histopathological analysis of colorectal biopsies and the typical finding of Hirschsprung disease is the absence
Rusul A. Abdul Hussein, Sahar A. H. AL-Sharqi, Ali E. Joda, Zaid Sharba   +3 more
doaj   +2 more sources

An Innovative and Alternative Technique in Total Colonic Hirschsprung Disease (TCHD) Treatment, Two Case Reports [PDF]

Clinical Case Reports
With reported occurrences ranging from 1% to 20%, total colonic Hirschsprung disease (TCHD) accounts for about 8% of Hirschsprung disease cases. The selection and sequencing of the surgical approach, access to parenteral nutrition, and collaborative care
Ali Khaksour, Jamshid Yousefi, Seyed Mohammad Ali Raisolsadat   +2 more
doaj   +2 more sources

Thymic Stromal Lymphopoietin–Driven B-Cell Hyperactivation Impairs Intestinal Epithelial Homeostasis Predisposing to Enterocolitis in Hirschsprung DiseaseSummaryWhat You Need to Know [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Hirschsprung-associated enterocolitis, a lethal complication of Hirschsprung’s disease—a prevalent congenital disorder with high morbidity—has a poorly understood pathogenesis.
Shiwei He, Ziyi Zheng, Lingdu Meng, Lin Lin, Zhe Wang, Jie Zhou, Jiaye Lin, Ran Yang, Yang Lin, Yanlei Huang, Zhihong Huang, Yanbing Huang, Yingjian Chen, Lizhi Li, Feng Chen, Rui Dong   +15 more
doaj   +2 more sources

Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial [PDF]

Nature Communications
Preoperative undernutrition is prevalent among children with Hirschsprung disease (HSCR). To evaluate whether preoperative nutritional support reduces the incidence of postoperative HSCR-associated enterocolitis (HAEC), we conducted a prospective ...
Hong-yi Zhang, Ke Chen, Yanmin Zhang, Tingting Gao, Yuanyuan Huang, Liang Ge, Yuhang Yuan, Guofeng Zhang, Heying Yang, Hongxia Ren, Jianghua Zhan, Weijue Xu, Xiang Liu, Tianqi Zhu, Jiexiong Feng   +14 more
doaj   +2 more sources

Surgical management of short-segment Hirschsprung disease [PDF]

World Journal of Pediatric Surgery
Hirschsprung disease (HSCR) is the most common congenital motility disorder of the intestine, characterized by the absence of ganglion cells in the myenteric and submucosal plexuses, leading to functional bowel obstruction.
Haley Etskovitz, Rosa S Kim, Sarah Ziqi Wang, Prathima Nandivada   +3 more
doaj   +2 more sources

Subtypes of Enteric Neurons in Hirschsprung Disease: A Comparison of Fully Ganglionic and Transitional Zone. [PDF]

Neurogastroenterol Motil
Neuronal subtype composition is comparable between transitional and fully ganglionic zones in children with Hirschsprung disease. Thus, our study did not support a major contribution of shifts in neuronal subtype composition to persistent postoperative bowel dysfunction. ABSTRACT Background Hirschsprung disease (HD) is characterized by aganglionosis of
Nebeling C, Lee-Theilen M, Gradhand E, Friedmacher F, Rolle U, Braun Y.   +5 more
europepmc   +2 more sources

Identification and characterisation of mucin abnormalities in the ganglionic bowel in Hirschsprung's disease [PDF]

, 2010
MDHirschsprung’s disease (HD) is a congenital abnormality of unknown origin, characterised by a lack of ganglion cells in the distal colon which results in functional colonic obstruction.
Speare, Ruth Marian
core   +4 more sources

TREATMENT OF HIRSCHSPRUNG DISEASE IN ADULTS [PDF]

Acta Biomedica Scientifica, 2012
The article presents our own experience of treatment of Hirschsprung disease in adults.
I. S. Moskvitin, B. V. Zaigraev, A. N. Plekhanov, A. I. Tovarshinov   +3 more
doaj   +1 more source

Identification and validation of the common pathogenesis and hub biomarkers in Hirschsprung disease complicated with Crohn’s disease

Frontiers in Immunology, 2022
BackgroundAlthough increasing evidence has supported that Hirschsprung disease (HSCR) is the risk factor for children developing Crohn’s disease (CD), the common mechanism of its co-occurrence remains unknown.
Jing Wang, Jing Wang, Zejian Li, Zejian Li, Jun Xiao, Jun Xiao, Luyao Wu, Luyao Wu, Ke Chen, Ke Chen, Tianqi Zhu, Tianqi Zhu, Chenzhao Feng, Didi Zhuansun, Didi Zhuansun, Xinyao Meng, Xinyao Meng, Jiexiong Feng, Jiexiong Feng   +18 more
doaj   +1 more source