The Properties of Scrambled Hirudins
Journal of Biological Chemistry, 1995 Scrambled hirudins serve as relevant folding intermediates during in vitro renaturation of the reduced/denatured hirudin. Eleven species of scrambled hirudins were isolated and structurally identified. Their properties, including their relative stability and the kinetics of their consolidation (disulfide reshuffling) to attain the native structure ...
Jui-Yoa Chang
exaly +3 more sources
Regarding the Use of Direct-Acting Anticoagulants of Animal Origin in Diabetic Retinopathy
Oftalʹmologiâ, 2023 Relevance. Diabetic retinopathy occupies one of the leading places in the frame of blindness and low vision. The very first changes in the retina in diabetic retinopathy are disorders of microcirculation and blood supply in the small vessels of the ...
I. V. Vorobyeva +5 more
doaj +1 more source
A review on Iranian Traditional Medicine about Leech Therapy in Polycystic Ovary Syndrome [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2019 Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Complementary medicine with a comprehensive and holistic approach in treating the diseases has become more popular in many ...
Maryam Bahman, Mojgan Tansaz
doaj +1 more source
The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.
Jiangying Zhu +6 more
doaj +1 more source
Pharmacokinetics study of recombinant hirudin in the plasma of rats using chromogenic substrate, ELISA, and radioisotope assays. [PDF]
PLoS ONE, 2013 AIM: To compare the analytical methods used to study the pharmacokinetics of recombinant hirudin in the plasma of rats that had been injected with (125)I-recombinant hirudin.
Su-Yun Jiang +3 more
doaj +1 more source
Catabolism of hirudin and thrombin-hirudin complexes in the rat [PDF]
Biochemical Journal, 1993 The metabolic fate of the anticoagulant protein, hirudin, and its complex with thrombin are presently unknown. Therefore we have labelled hirudin and human thrombin-hirudin complex with the residualizing label dilactitol-125I-tyramine (*I-DLT) in order to identify their tissue sites of catabolism in the rat.
Bichler, Johann +2 more
openaire +2 more sources
Preparation of monoclonal antibodies to hirudin and hirudin peptides [PDF]
European Journal of Biochemistry, 1990 A panel of four monoclonal antibodies was obtained against hirudin, a potent and specific inhibitor of thrombin, by immunizing three groups of mice with protein conjugates made of recombinant desulfatohirudin (group I) or two synthetic peptides representing the C‐terminal sequences 40–65 (group II) and 52–65 (group III) of hirudin.
J M, Schlaeppi +3 more
openaire +2 more sources
Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway [PDF]
Acta Cirúrgica BrasileiraPurpose: To reveal the role and underlying mechanism of hirudin in renal fibrosis. Methods: The unilateral ureteral obstruction (UUO) rat model and ferroptosis activator RSL3-induced human kidney proximal tubular epithelial cells (HK-2) were established.
Fang Lan +4 more
doaj +1 more source
Allergic anaphylaxis due to subcutaneously injected heparin
Allergy, Asthma & Clinical Immunology, 2013 Heparins are one of the most used class of anticoagulants in daily clinical practice. Despite their widespread application immune-mediated hypersensitivity reactions to heparins are rare. Among these, the delayed-type reactions to s.c.
Anders Diana, Trautmann Axel
doaj +1 more source
Comparative Study of Hirudins and Encoding Genes in Hirudo nipponia and Hirudo tianjinensis
BiologyThis study systematically compared the genetic characteristics and functional activities of hirudins and their encoding genes between Hirudo nipponia (Hnip1–3) and Hirudo tianjinensis (Htia1–3) through bioinformatics analysis, recombinant protein ...
Jingjing Yin +7 more
doaj +1 more source