Results 1 to 10 of about 816 (186)

Comparative Study of Hirudins and Encoding Genes in Hirudo nipponia and Hirudo tianjinensis [PDF]

Biology
This study systematically compared the genetic characteristics and functional activities of hirudins and their encoding genes between Hirudo nipponia (Hnip1–3) and Hirudo tianjinensis (Htia1–3) through bioinformatics analysis, recombinant protein ...
Jingjing Yin, Zichao Liu, Yunfei Yu, Anping Wang, Zuhao Huang, Lizhou Tang, Fang Zhao, Gonghua Lin   +7 more
doaj   +2 more sources

Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway [PDF]

Acta Cirúrgica Brasileira
Purpose: To reveal the role and underlying mechanism of hirudin in renal fibrosis. Methods: The unilateral ureteral obstruction (UUO) rat model and ferroptosis activator RSL3-induced human kidney proximal tubular epithelial cells (HK-2) were established.
Fang Lan, Chunli Long, Huimin Huang, Yongxiang Xie, Wei Shi   +4 more
doaj   +2 more sources

Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors [PDF]

Nature Communications
Potent and selective inhibition of the structurally homologous proteases of coagulation poses challenges for drug development. Hematophagous organisms frequently accomplish this by fashioning peptide inhibitors combining exosite and active site binding ...
Haixiang Yu, Shekhar Kumar, James W. Frederiksen, Vladimir N. Kolyadko, George Pitoc, Juliana Layzer, Amy Yan, Rachel Rempel, Samuel Francis, Sriram Krishnaswamy, Bruce A. Sullenger   +10 more
doaj   +2 more sources

Regarding the Use of Direct-Acting Anticoagulants of Animal Origin in Diabetic Retinopathy

Oftalʹmologiâ, 2023
Relevance. Diabetic retinopathy occupies one of the leading places in the frame of blindness and low vision. The very first changes in the retina in diabetic retinopathy are disorders of microcirculation and blood supply in the small vessels of the ...
I. V. Vorobyeva, V. V. Biryukov, M. A. Frolov, A. M. Frolov, U. S. Pliaskina, S. Shallah   +5 more
doaj   +1 more source

A review on Iranian Traditional Medicine about Leech Therapy in Polycystic Ovary Syndrome [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2019
Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Complementary medicine with a comprehensive and holistic approach in treating the diseases has become more popular in many ...
Maryam Bahman, Mojgan Tansaz
doaj   +1 more source

The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells [PDF]

Acta Cirúrgica Brasileira, 2019
Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.
Jiangying Zhu, Xinyuan Pan, Bojie Lin, Guanyu Lin, Rohan Pradhan, Feiwen Long, Guoqian Yin   +6 more
doaj   +1 more source

Pharmacokinetics study of recombinant hirudin in the plasma of rats using chromogenic substrate, ELISA, and radioisotope assays. [PDF]

PLoS ONE, 2013
AIM: To compare the analytical methods used to study the pharmacokinetics of recombinant hirudin in the plasma of rats that had been injected with (125)I-recombinant hirudin.
Su-Yun Jiang, Jian Jiao, Ting-Ting Zhang, Yong-Ping Xu   +3 more
doaj   +1 more source

Allergic anaphylaxis due to subcutaneously injected heparin

Allergy, Asthma & Clinical Immunology, 2013
Heparins are one of the most used class of anticoagulants in daily clinical practice. Despite their widespread application immune-mediated hypersensitivity reactions to heparins are rare. Among these, the delayed-type reactions to s.c.
Anders Diana, Trautmann Axel
doaj   +1 more source

Preparation of monoclonal antibodies to hirudin and hirudin peptides [PDF]

European Journal of Biochemistry, 1990
A panel of four monoclonal antibodies was obtained against hirudin, a potent and specific inhibitor of thrombin, by immunizing three groups of mice with protein conjugates made of recombinant desulfatohirudin (group I) or two synthetic peptides representing the C‐terminal sequences 40–65 (group II) and 52–65 (group III) of hirudin.
J M, Schlaeppi, S, Vekemans, H, Rink, J Y, Chang   +3 more
openaire   +2 more sources

Catabolism of hirudin and thrombin-hirudin complexes in the rat [PDF]

Biochemical Journal, 1993
The metabolic fate of the anticoagulant protein, hirudin, and its complex with thrombin are presently unknown. Therefore we have labelled hirudin and human thrombin-hirudin complex with the residualizing label dilactitol-125I-tyramine (*I-DLT) in order to identify their tissue sites of catabolism in the rat.
Bichler, Johann, Baynes, John W., Thorpe, Suzanne R.   +2 more
openaire   +2 more sources