Results 11 to 20 of about 816 (186)

From ancient leech to direct thrombin inhibitors and beyond: New from old [PDF]

, 2022
Medicinal leeches have been used in health care since before written history, with widely varying popularity over the centuries. Nowadays, medicinal leech therapy is mainly used in plastic and reconstructive microsurgery, with new interesting potential ...
Minelli S., Montinari M. R.
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Bakteriämie und Schocklunge im Tierexperiment [PDF]

, 1986
Der Artikel befindet sich unter "Tagungsberichte", ein anderer Inhaltsverzeichnis gibt es ...
Fritz, Hans, Jochum, Marianne, Siebeck, Matthias, Welter, H. F.   +3 more
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Elucidation of the disulfide folding pathway of hirudin by a topology-based approach [PDF]

, 2003
A theoretical model for the folding of proteins containing disulfide bonds is introduced. The model exploits the knowledge of the native state to favour the progressive establishment of native interactions.
De Filippis, V., Maritan, A., Micheletti, C., Seno, F.   +3 more
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A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis [PDF]

, 2018
A key role of both coagulation and vascular thrombosis has been reported since the first descriptions of multiple sclerosis (MS). Subsequently, the observation of a close concordance between perivascular fibrin(ogen) deposition and the occurrence of ...
Adams, Adams, Akassoglou, Akassoglou, Akenami, Akenami, Albright, Alizadeh, Alonso, Amor, Antoniak, Beggs, Bidot, Bitsch, Boesen, Brkic, Bronstein, Brunetti, Castellino, Cesarman-Maus, Chapman, Chelmicka-Szorc, Claudio, Compston, Coughlin, Cuzner, Danø, Davalos, Davalos, Davidson, Davie, De Luca, Dekaban, Deschepper, Donovan, East, Ed Rainger, Engelmann, Esmon, Esmon, Fan, Fan, Farber, Feldman, Ferguson, Festoff, Field, Fiorini, Flick, Fog, Friedman, Garcia-Monco, García, Garg, Genc, Gloor, Griffin, Griffin, Guenther, Gveric, Göbel, Göbel, Göbel, Hafler, Han, Horstman, Huszak, Inaba, Inoue, Iong, Jacob, Jones, Kalaria, Kirichuk, Kirk, Kirk, Knauer, Koudriavtseva, Koudriavtseva, Koudriavtseva, Koudriavtseva, Kreutzberg, Kuhlmann, Kwon, Lane, Langer, Lassmann, Lassmann, Lassmann, Lesny, Liddelow, Lider, Lin, Lin, Lock, Lu, Mahmood, Mandoj, Marik, Mechelli, Miranda, Moll, Murray, Park, Parsons, Paterson, Perez, Persson, Persson, Petersen, Phillips, Pike, Plantone, Plumb, Putnam, Putnam, Rand, Reese, Reinhard, Roizin, Ryu, Ryu, Saberi, Savitky, Seeds, Seeds, Sheremata, Simón, Smith, Sobel, Soon, Sotnikov, Spadaro, Starossom, Starossom, Stavrou, Stolz, Teesalu, Tennent, Ugarova, Uzawa, van der Poll, Varga, Verrall, Wachowicz, Wakefield, Weisel, Whitlock, Wittinghofer, Wolter, Wright, Xue, Yadav, Yamaji, Yates, Yuksel, Zhang, Ziliotto, Zivadinov   +158 more
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Prediction of Thrombin Inhibitor Peptides from Various Habitats Using Machine Learning [PDF]

, 2023
Thrombin is the key enzyme in the pathogenesis of most cardiovascular diseases. A new class of anticoagulation drugs, direct thrombin inhibitors (DTI) have greatly improved patient care.
Balakrishnan, Nivedha
core   +2 more sources

Design of small-molecule active-site inhibitors of the S1A family proteases as procoagulant and anticoagulant drugs [PDF]

, 2017
Vitamin K antagonists (VKA) have long been the default drugs for anticoagulant management in venous thrombosis. While efficacious, they are difficult to use due to interpatient dose–response variability and the risks of bleeding.
Banner D. W., Bode W., Budovich A., Cool D. E., Fritz H., Giansily-Blaizot M., Himber J., Mather T., Peter M. Fischer, Sun W. Y.   +9 more
core   +2 more sources

Bivalirudin in the Treatment of Coronary Artery Disease [PDF]

, 2014
Periprocedural anticoagulation continues to be a vital aspect in the management of coronary artery disease. Bivalirudin is a relatively new drug that has caught much attention in the last decade, especially in the context of percutaneous coronary ...
Jayasinghe, Rohan, Maxwell, Ryan, Sridhar, Vaishnavi   +2 more
core   +3 more sources

Optimierung synthetischer Inhibitoren des Gerinnungsfaktors Xa vom 4-Amidinobenzylamid-Typ [PDF]

, 2005
Die Entwicklung von wirksamen und sicheren Antikoagulantien, die ergänzend und anstelle der bisherigen Standardtherapeutika zur Behandlung thromboembolischer Erkrankungen eingesetzt werden können, ist weltweit ein aktuelles Forschungsziel vieler Firmen ...
Steinmetzer, Torsten (Dr.), Stürzebecher, Anne   +1 more
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Prospection of Peptide Inhibitors of Thrombin from Diverse Origins Using a Machine Learning Pipeline [PDF]

, 2023
Thrombin is a key enzyme involved in the development and progression of many cardiovascular diseases. Direct thrombin inhibitors (DTIs), with their minimum off-target effects and immediacy of action, have greatly improved the treatment of these diseases.
Anastasiu, David C., Balakrishnan, Nivedha, Downey, Taylor, Kashyap, Prarthna, Katkar, Rahul, Pham, Peter V., Ramasubramanian, Anand K.   +6 more
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Measurement of Active Thrombin Bound to Circulating D‐Dimers as a Sensitive Biomarker for Prothrombotic Conditions

Journal of Clinical Laboratory Analysis, EarlyView.
Scheme of preparation of D‐dimers and evaluation of D‐dimer‐bound thrombin activity. Thrombin bound to fibrin participates in ongoing fibrinogen transformation and its inhibition is impeded. Our detection system may aid in identifying patients at risk of recurrent thrombotic events or complications, regardless of the origin of the acute health problem.
Jana Stikarova, Leona Chrastinova, Kristyna Svobodova, Marek Havlicek, Jan Louzil, Eliska Ceznerova, Alzbeta Hlavackova, Ondrej Pastva, Pavla Pecherkova, Ingrid Hrachovinova, Ondrej Kucerka, Roman Kotlin, Petr Soukup, Peter Salaj, Martin Maly, Jiri Suttnar   +15 more
wiley   +1 more source