Results 1 to 10 of about 2,858 (119)
Asian Journal of Pharmaceutical SciencesAtherosclerosis (AS) is a progressive inflammatory disease, and thrombosis most likely leads to cardiovascular morbidity and mortality globally. Thrombolytic drugs alone cannot completely prevent thrombotic events, and treatments targeting thrombosis ...
Mengying Cheng +5 more
doaj +5 more sources
Self-regulated hirudin delivery for anticoagulant therapy [PDF]
Science Advances, 2020 Polymeric nanogel with on-demand release of hirudin prevents and inhibits clot formation.
Xiao Xu, Shiyang Shen, Can Zhang
exaly +3 more sources
Asian Journal of Pharmaceutical Sciences, 2022 Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy being the main prevention and treatment strategy. Recombinant hirudin (r-hirudin) is a direct thrombin inhibitor that can potentially prevent thrombosis via ...
Mengfang Wu +9 more
doaj +3 more sources
R-Hirudin as Anticoagulant in Regular Hemodialysis Therapy: Finding of Therapeutic R-Hirudin Blood/Plasma Concentrations and Respective Dosages [PDF]
Clinical and Applied Thrombosis/Hemostasis, 1999 Recently heparin-induced thrombocytopenia type II has been diagnosed more frequently and does not exclude hemodialysis patients. Up to now, recombinant hirudin is the only available anticoagulant showing no immunologic cross reactions with heparin.
Elke Bucha, Goetz Nowak
exaly +3 more sources
Traditional Chinese medicine in the treatment of diabetic kidney disease: the mechanisms of signaling pathways regulations [PDF]
Frontiers in EndocrinologyDiabetic kidney disease (DKD) represents a diabetes-driven microvascular complication characterized by renal physiological and metabolic disorders and is considered a top-ranking trigger of progression to end-stage renal disease and death in diabetic ...
Wencan Li +7 more
doaj +2 more sources
Renal Failure, 2004 Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated.
Ortrud Vargas Hein +2 more
exaly +3 more sources
In situ formed depot of elastin-like polypeptide-hirudin fusion protein for long-acting antithrombotic therapy. [PDF]
Proc Natl Acad Sci U S AThrombosis, induced by abnormal coagulation or fibrinolytic systems, is the most common pathology associated with many life-threatening cardio-cerebrovascular diseases. However, first-line anticoagulant drugs suffer from rapid drug elimination and risk of hemorrhagic complications. Here, we developed an in situ formed depot of elastin-like polypeptide (
Tian X +7 more
europepmc +3 more sources
Determinants of reduced antiplatelet effect of aspirin in patients with stable coronary artery disease. [PDF]
PLoS ONE, 2015 Aspirin is a cornerstone in management of coronary artery disease (CAD). However, considerable variability in the antiplatelet effect of aspirin has been reported.To investigate independent determinants of reduced antiplatelet effect of aspirin in stable
Sanne Bøjet Larsen +5 more
doaj +1 more source
Performance Characteristics of DOAC Dipstick in Determining Direct Oral Anticoagulants in Urine
Clinical and Applied Thrombosis/Hemostasis, 2021 Testing for direct oral anticoagulants (DOACs) in patient urine may facilitate medical treatment decisions. The aim of this study was to investigate interobserver variability by 2 independent observers compared to laboratory staff in the visual ...
Job Harenberg MD +5 more
doaj +1 more source
Hirudotherapy in Medicine and Dentistry [PDF]
Journal of Clinical and Diagnostic Research, 2015 The concept of Unani medicine is based on balancing body humours, the imbalance of which causes diseases. The application of leech therapy in medical and dental science is well recognized. Although easy and non-invasive, complications also exist.
Kunal Jha +3 more
doaj +1 more source