Results 31 to 40 of about 3,003 (174)

Anticoagulation for patients with heparin-induced thrombocytopenia using recombinant hirudin during cardiopulmonary bypass [PDF]

, 2002
Heparin-induced thrombocytopenia (HIT) is a common complication of heparin therapy. There are three types of HIT. In the majority of patients, thrombocytopenia is modest and resolves without sequelae (HIT I).
Hong Liu, Neal W Fleming, Fleming, Neal W, Peter G Moore, Moore, Peter G, Liu, Hong   +5 more
core   +1 more source

Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side‐effects after radiation therapy and as countermeasure against radiation exposure [PDF]

Journal of Thrombosis and Haemostasis, 2004
The small bowel is a dose-limiting normal tissue in radiation therapy of malignancies in the abdomen and pelvis, as well as an important determinant of survival after non-therapeutic radiation exposure. Irradiation of normal tissues, including intestine, causes loss of vascular thromboresistance and upregulation of thrombin receptors. Radiation-induced
J, Wang, H, Zheng, X, Ou, C M, Albertson, L M, Fink, J-M, Herbert, M, Hauer-Jensen   +6 more
openaire   +2 more sources

Measurement of Active Thrombin Bound to Circulating D‐Dimers as a Sensitive Biomarker for Prothrombotic Conditions

Journal of Clinical Laboratory Analysis, Volume 40, Issue 11, June 2026.
Scheme of preparation of D‐dimers and evaluation of D‐dimer‐bound thrombin activity. Thrombin bound to fibrin participates in ongoing fibrinogen transformation and its inhibition is impeded. Our detection system may aid in identifying patients at risk of recurrent thrombotic events or complications, regardless of the origin of the acute health problem.
Jana Stikarova, Leona Chrastinova, Kristyna Svobodova, Marek Havlicek, Jan Louzil, Eliska Ceznerova, Alzbeta Hlavackova, Ondrej Pastva, Pavla Pecherkova, Ingrid Hrachovinova, Ondrej Kucerka, Roman Kotlin, Petr Soukup, Peter Salaj, Martin Maly, Jiri Suttnar   +15 more
wiley   +1 more source

CYP2C19 Polymorphism and Platelet Aggregation‐Associated Risks in Atrial Fibrillation Patients Undergoing PCI

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT CYP2C19 genetic polymorphisms impact the antiplatelet effect of clopidogrel and associate with ischemic and bleeding risk in patients undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the association of CYP2C19 and platelet reactivity (PR) with these risks, in atrial fibrillation (AF) patients undergoing PCI ...
Diona Gjermeni, Sofia Szabó, Viktoria Anfang, Hannah Vetter, Carina Juelch, Svenja Rademacher, Tian Li, Stefan Leggewie, David Hesselbarth, Daniel Duerschmied, Dietmar Trenk, Dirk Westermann, Christoph B. Olivier   +12 more
wiley   +1 more source

Diabetes and Delayed Wound Healing: Molecular Mechanisms and Dermatological Interventions

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Diabetes mellitus is a global burden that affects wound healing at nearly every stage, transforming what should be a coordinated and self‐limited repair process into a chronic, non‐healing state. In diabetic patients, sustained hyperglycemia drives persistent inflammation, impaired angiogenesis, fibroblast dysfunction and extracellular matrix ...
Sasha Jreije, Marwan Fadel, Carl Karam, Hilda E. Ghadieh, Antoine Ghanem   +4 more
wiley   +1 more source

Expression of hirudin fusion proteins in mammalian cells : A strategy for prevention of intravascular thrombosis

, 1998
Background - Intravascular thrombosis occurs in disorders of diverse pathogeneses, including allograft and xenograft rejection. In this in vitro study, we describe an approach for tethering the specific thrombin inhibitor hirudin to plasma membranes as ...
George, Andrew J.T., John H. McVey, Edward G. D. Tuddenham, Geoffrey Kemball-Cook, Lechler, Robert I.,, Lechler, Robert I., Tuddenham, Edward G.D., Anthony Dorling, Kristian Riesbeck, George, Andrew J.T.,, Dorling, Anthony,, Dorling, Anthony, Daxin Chen, Robert I. Lechler, Kemball-Cook, Geoffrey,, Chen, Daxin, Andrew J. T. George, Chen, Daxin,, Kemball-Cook, Geoffrey, McVey, John H., Tuddenham, Edward G.D.,, Riesbeck, Kristian,, Lund University., McVey, John H.,, Riesbeck, Kristian   +24 more
core   +1 more source

Targeted delivery for treatments for restenosis and vein graft disease [PDF]

, 2012
Surgery to restore blood flow in arteries blocked by atherosclerotic plaque is a common treatment in cardiovascular disease. Longtermcomplications of surgical treatment are vein graft disease and restenosis, a renarrowing of the blood vessel after ...
Thomas, Anita C
core   +1 more source

Albumin Restores Endothelial Cell Mitochondrial Morphology in Patients With Decompensated Cirrhosis

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background & Aims Endothelial cell (EC) activation is a critical driver of disease progression in cirrhosis, contributing to acute decompensation (AD) and acute‐on‐chronic liver failure (ACLF). Although human albumin administration improves EC function in cirrhotic patients with hypoalbuminemia, its direct effects on ECs remain unclear.
Susan E. Fischer, Rudmer J. Postma, Roel Bijkerk, Annarein J. C. Kerbert, Anton Jan van Zonneveld, Minneke J. Coenraad   +5 more
wiley   +1 more source

Hirudin in heparin-induced thrombocytopenia

, 2002
Heparin-induced thrombocytopenia (HIT), a serious side effect of heparin treatment, requires alternative anticoagulation in most affected patients. The recombinant hirudin (r-hirudin) lepirudin has been approved for this purpose after two prospective ...
Greinacher, Andreas, Lubenow, Norbert,
core   +1 more source

988-4 Hemorrhagic Stroke Associated with High aPTTs Following Thrombolytic Therapy and Heparin or Hirudin

Journal of the American College of Cardiology, 1995
In GUSTO lla, 2564 patients with acute coronary syndrome with ST deviation and symptoms within 12 hours were randomized to hirudin (0.6 mg/kg bolus, 0.6 mg/kg/hr infusion with out adjustment) or IV heparin (5,000 U bolus, 1100 to 1300 U/hr adjusted tD a target aPTF of 60–90 seconds) for 3–5 days.
Granger, Cristopher, Van de Wert, Frans, Horrigan, Mark, Califf, Robert, Woodlief, Lynn, Topol, Eric   +5 more
openaire   +1 more source