Results 51 to 60 of about 5,082,017 (204)

Proteinase-activated receptors (PARs) as targets for antiplatelet therapy [PDF]

, 2016
Since the identification of the proteinase-activated receptor (PAR) family as mediators of serine protease activity in the 1990s, there has been tremendous progress in the elucidation of their pathophysiological roles.
Bushell, Trevor, Cunningham, Margaret, McIntosh, Kathryn, Plevin, Robin, Sloan, Graeme   +4 more
core   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, Volume 13, Issue 4, 19 January 2026.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Lepirudin in the management of patients with heparin-induced thrombocytopenia

Biologics: Targets & Therapy, 2008
Sirak PetrosDepartment of Internal Medicine, University of Leipzig, Leipzig, GermanyAbstract: Lepirudin, a recombinant hirudin, is a direct irreversible thrombin inhibitor by binding to both free and clot-bound thrombin.
Sirak Petros
doaj  

Malignant atrophic papulosis treated with eculizumab and hirudin: a fatal case report and literature review

Frontiers in Cardiovascular Medicine
BackgroundMalignant atrophic papulosis (MAP) is a rare obliterative vasculopathy whose etiology and pathophysiological mechanisms remain unknown, and the treatment is still empirical. It can involve multiple systems, especially the gastrointestinal tract
Linna Yu, Linna Yu, Yun Wang, Yun Wang, Xiaodan Tang, Xiaodan Tang, Xueru Zhao, Xueru Zhao, Zhengji Song, Zhengji Song   +9 more
doaj   +1 more source

Advantages and limitations of clopidogrel response testing methods [PDF]

, 2012
nem
Njegomirović Srđana, Ostojić Miodrag, Prostran Milica, Todorović Zoran, Đukanović Nina   +4 more
core   +1 more source

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

Relevance of Medicinal Leeches in plastic and reconstructive surgery - a literature review

Quality in Sport
Background. Medicinal leeches, once emblematic of pre-modern bloodletting practices, have re-emerged as valuable therapeutic tools in contemporary medicine that is now an FDA-approved treatment [1].
Joanna Słuchocka, Tymon Lewalski, Martyna Florczyk, Lidia Płuciennik, Oskar Lewalski, Klaudia Jeruć   +5 more
doaj   +1 more source

Combined drug anti-deep vein thrombosis therapy based on platelet membrane biomimetic targeting nanotechnology.

Biomaterials
After orthopedic surgeries, such as hip replacement, many patients are prone to developing deep vein thrombosis (DVT), which in severe cases can lead to fatal pulmonary embolism or major bleeding.
Hang Xiao, Xiangrui Meng, Songtao Li, Zhiyong Li, Shuo Fang, Yaonan Wang, Jing Li, Jianyuan Tang, Li Ma   +8 more
semanticscholar   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

Small, Volume 22, Issue 1, 2 January 2026.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha, Yeonji Kim, Subin Park, Hu‐Lin Jiang, Jae‐Young Lee, Daesik Kim, Jee‐Heon Jeong   +6 more
wiley   +1 more source

New Advances in Biologic Treatment for Malignant Atrophic Papulosis: A Systematic Review

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Malignant atrophic papulosis (MAP) is the systemic subtype of Degos disease, characterized by high lethality. Currently there is no standardized treatment protocol. Steroids and immunosuppressive therapies result in limited effectiveness. Biologic treatments offer promising therapeutic potential for MAP and significantly improve prognosis ...
Jia-Wei Liu, Xiao Ma, Dong-Lai Ma, Zhirong Yao   +3 more
wiley   +1 more source