Results 61 to 70 of about 5,082,017 (204)

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): The Multifaceted Biology, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Summary of PCSK9 inhibitor mechanisms. PCSK9 inhibitors (PCSK9‐i) primarily lower LDL‐cholesterol (LDL‐C) by blocking PCSK9‐mediated degradation of hepatic LDL receptors (LDLR), enhancing LDL clearance. Beyond LDLR‐dependent effects, PCSK9‐i exert multiple benefits via LDLR‐independent pathways.
Jia Kuang, Lei Hao, Meibiao Zhang, Zhao Yang   +3 more
wiley   +1 more source

Centromeric Sequences in Ogataea polymorpha Genome Enable Development of Stable Multigene Expression Plasmid Tools

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The centromeric sequences of Ogataea polymorpha, a methylotrophic non‐conventional yeast, were characterised for the first time and support the development of new genetically stable centromeric plasmids with high genetic stability and compatibility, providing powerful genetic toolboxes for the synthetic biology and metabolic engineering‐driven ...
Yanfei Cheng, Yuanyuan Shi, Ning Sun, Xin Zhang, Mengwei Sun, Xiuping He   +5 more
wiley   +1 more source

Clopidogrel responsiveness in chronic kidney disease patients with acute coronary syndrome [PDF]

, 2014
Objective: Cardiovascular diseases are the leading cause of death in patients with chronic kidney disease (CKD). There is conflicting evidence about effect of CKD on clopidogrel responsiveness.
Ali Kemal Kalkan, Ender Öner, Hale Ünal Aksu, Hüseyin Aksu, Mehmet Ertürk, Muhammed Hulusi Satılmışoğlu, Nilgün Işıksaçan, Ömer Çelik   +7 more
core   +1 more source

Emerging Strategies for Platelet‐Modified Nanoparticles in Targeted Tumor Therapy

Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.
This review highlights innovative strategies using platelet‐modified nanoparticles to target tumors more precisely. By mimicking platelet functions, these biomimetic carriers improve tumor homing, enhance drug delivery, and reduce immune clearance.
Chunyu Bai, Lan Sun, Yimin Cui, Huan Meng, Jiulong Li, Qian Xiang   +5 more
wiley   +1 more source

Treatment of cutaneous leishmaniasis lesion caused by Leishmania major using leech therapy in BALB/c mice

Journal of Vector Borne Diseases
Background & objectives: Amphotericin B, Allopurinol, Glucantime and Beta-Glucan are the main drugs currently used for the treatment of cutaneous leishmaniasis.
Leila Shirani-Bidabadi
doaj   +1 more source

IMPLICATION OF LEECH THERAPY AND ASBAB-E-SITTA ZAROORIYAH IN THE PREVENTION AND TREATMENT OF VARICOSE VEINS: A COMPREHENSIVE REVIEW

International Journal of Advanced Research
Varicose veins are characterized by abnormally twisted, dilated superficial vessels that are caused by the inefficient or defective valves within the vein. It is currently a prevalent disease with the incidence varying globally between 10% and 60%.
Mohd. Maruf Khan, Mehmooda Begum, Arif Anees, Akanksha Mishra   +3 more
semanticscholar   +1 more source

Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies

Diabetes/Metabolism Research and Reviews, Volume 41, Issue 7, October 2025.
ABSTRACT Diabetic kidney disease (DKD) is the most severe complication of diabetes mellitus and has poor prognosis, often progressing to end‐stage renal disease, causing substantial morbidity and mortality globally. While the pathogenesis of DKD has been extensively characterised, including glomerular hyperfiltration, podocyte injury, and ...
Yi Lv, Chen Ye, Zixi Li, Jiajia Ye, Huanhuan Cao, Chun Zhang, Huajun Jiang, Yumei Wang   +7 more
wiley   +1 more source

Comparison of leeching and heparin therapy in management of acute venous congestion of limbs in rat

Pharmaceutical and Biomedical Research, 2016
Acute venous congestion leads to blood stasis in the tissue and impaired blood perfusion. Using medicinal leech is an old method for reducing tissue congestion.
Seyed Abdollah Mousavi, Maryam Ghasemi, Seyed Jaber Mousavi, Seyyed Saied Mousavi Darka, Vafa Bagheri   +4 more
doaj  

Diabetic Kidney Disease‐Associated Pathological Angiogenesis: The Role of Aquaporin‐1

Journal of Diabetes, Volume 17, Issue 10, October 2025.
Hyperglycemia upregulates AQP1 expression in renal endothelial cells, promoting abnormal angiogenesis. Structurally and functionally immature vessels lead to glomerular capillary leakage, proteinuria, and progressive renal injury. Targeting AQP1 may attenuate abnormal angiogenesis in DKD and slow disease progression.
Fengyi Zhang, Jiayi Zhang, Xin Wang, Yaxin Chen, Ziyang Cheng, Jingjing Pan, Yufeng Zhang, Yujie Li, Wenbo Wang, Linhua Zhao   +9 more
wiley   +1 more source

Prevention of restenosis after percutaneous transluminal coronary angioplasty: the search for a "magic bullet" [PDF]

, 1991
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Hermans, W.R.M. (Walter), Rensing, B.J.W.M. (Benno), Serruys, P.W.J.C. (Patrick), Strauss, B.H. (Bradley)   +3 more
core