Results 41 to 50 of about 3,003 (174)

Scrotal Hirudiniasis: The Mysterious Migration of a Leech Into the Scrotum: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Hirudiniasis, or leech infestation, is a rare parasitic condition typically involving external skin or mucosal surfaces. We report a case of scrotal hirudiniasis, an 11 cm long leech discovered within the scrotal sac of a 15‐year‐old male.
Pranto Chakroborty, Md. Abdul Quadir
wiley   +1 more source

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures, Volume 7, Issue 3, March 2026.
Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
wiley   +1 more source

Use of Ecarin Clotting Time (ECT) with Lepirudin Therapy in Heparin-Induced Thrombocytopenia and Cardiopulmonary Bypass

, 2023
Heparin-induced thrombocytopenia (HIT) is described as an allergy-like adverse reaction to heparin. It is a potentially severe complication of heparin therapy that can result in serious or life–threatening venous or arterial thromboembolic events. In the
M. Charlene Fabrizio
core   +1 more source

Monitoring anticoagulant therapy by activated partial thromboplastin time: hirudin assessment. An evaluation of native blood and plasma assays

, 1994
Recombinant hirudin (RH) is a new anticoagulant for prophylaxis and treatment of venous and arterial thrombosis. To which extent the activated partial thromboplastin time (APTT) is suitable for monitoring of RH has not been properly evaluated.
Berckmans, R. J., Rijnierse, J. J., Nurmohamed, M. T., Berends, F., Hommes, D. W., Morriën-Salomons, W. M., Sturk, A.   +6 more
core   +1 more source

Hirudin: Initial results in acute myocardial infarction, unstable angina and angioplasty

, 1995
The central role of thrombosis in the pathogenesis of acute myocardial infarction, unstable angina and complications after angioplasty has led to intense interest in developing more effective antithrombotic agents for these disorders.
Cannon, Christopher P., Braunwald, Eugene   +1 more
core   +1 more source

Retention of critical platelet hemostatic functions of amotosalen‐UVA pathogen‐reduced cryoprecipitated fibrinogen complex

Transfusion, Volume 66, Issue 2, Page 393-404, February 2026.
Abstract Background Cryoprecipitate Anti‐Haemophilic Factor (CRYO‐AHF) is enriched for fibrinogen, VWF, FVIII, FXIII and fibronectin, but has short post‐thaw expiration due to risk of transfusion‐transmitted infection (TTI) limiting availability for rapid treatment.
Florian Tupin, Clarisse Mouriaux, Michelle Gatmaitan, Kaja Kaastrup, Subramanian Yegneswaran, Laurence Corash, Pierre H. Mangin   +6 more
wiley   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, Volume 13, Issue 4, 19 January 2026.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

A recombinant peptide, hirudin, potentiates the inhibitory effects of stealthy liposomal vinblastine on the growth and metastasis of melanoma

, 2008
The metastasis of tumor cells is one of the major obstacles to successful clinical therapy. A treatment strategy by incorporating a specific inhibitor of thrombin, recombinant hirudin with stealthy liposomal vinblastine, was used in this study for ...
Wang, Jian-Cheng, Jian-Cheng Wang, Qiang Zhang, Ji-Hui Zhao, Zhao, Ji-Hui, Zhang, Xuan, Hua Zhang, Zhang, Qiang, Wang, Xue-Qing, Lu, Wan-Liang, Zhang, Hua, Liu, Yang, Yang Liu, Guo, Rong-Rong, Xue-Qing Wang, Xuan Zhang, Rong-Rong Guo, Wan-Liang Lu   +17 more
core   +1 more source

Treatment of cutaneous leishmaniasis lesion caused by Leishmania major using leech therapy in BALB/c mice

Journal of Vector Borne Diseases
Background & objectives: Amphotericin B, Allopurinol, Glucantime and Beta-Glucan are the main drugs currently used for the treatment of cutaneous leishmaniasis.
Leila Shirani-Bidabadi
doaj   +1 more source