A randomized clinical trial of unfractioned heparin for treatment of sepsis (the HETRASE study): design and rationale [NCT00100308] [PDF]
, 2006 Introduction Infection promotes coagulation via a large number of molecular and cellular mechanisms, and this procoagulant activity has boosted basic and clinical research using anticoagulant molecules as therapeutic tools in sepsis.
Aguirre Daniel +6 more
core +1 more source
Thrombosis Journal, 2010 Background Poor platelet inhibition by aspirin or clopidogrel has been associated with adverse outcomes in patients with cardiovascular diseases.
Lorenz Reinhard +5 more
doaj +1 more source
Thrombin Generation in Vitreous and Subretinal Fluid of Patients with Retinal Detachment [PDF]
, 2018 Purpose: To measure prothrombin fragments (F1+2) and thrombin-antithrombin complex (TAT) in vitreous and subretinal fluid (SRF) of rhegmatogenous retinal detachment (RRD) patients and to validate and further specify our earlier finding of increased ...
Bastiaans, J. (Jeroen) +4 more
core +1 more source
Scrotal Hirudiniasis: The Mysterious Migration of a Leech Into the Scrotum: A Case Report
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Hirudiniasis, or leech infestation, is a rare parasitic condition typically involving external skin or mucosal surfaces. We report a case of scrotal hirudiniasis, an 11 cm long leech discovered within the scrotal sac of a 15‐year‐old male.
Pranto Chakroborty, Md. Abdul Quadir
wiley +1 more source
Recombinant Neorudin for the Prevention of Deep-Vein Thrombosis After Spinal-Cord Injury
Drug Design, Development and Therapy, 2023 Yu-Bin Liu,1,2 Yun Liu,1,3 Lin Zhang,1 Xing-Chen Zhou,1 Bo-Yuan Ren,1 Can Zheng,1 Chun-Hua Hao,4 Wei-Ting Wang,4 Xia Xia,5 Gang-Qiao Zhou,1,3 Chu-Tse Wu,1 Ji-De Jin1 1Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation ...
Liu YB +11 more
doaj
Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation [PDF]
, 2006 Disseminated intravascular coagulation (DIC) is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular formation of fibrin, and diffuse hemorrhages, due
Lippi Giuseppe +2 more
core +2 more sources
Small Structures, Volume 7, Issue 3, March 2026.Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan +9 more
wiley +1 more source
A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction [PDF]
, 1997 BACKGROUND: Among physicians who treat patients with acute myocardial infarction, there is controversy about the magnitude of the clinical benefit of primary (i.e., immediate) coronary angioplasty as compared with thrombolytic therapy.
Ellis, S.G. (Stephen) +1 more
core +1 more source
Transfusion, Volume 66, Issue 2, Page 393-404, February 2026.Abstract Background Cryoprecipitate Anti‐Haemophilic Factor (CRYO‐AHF) is enriched for fibrinogen, VWF, FVIII, FXIII and fibronectin, but has short post‐thaw expiration due to risk of transfusion‐transmitted infection (TTI) limiting availability for rapid treatment.
Florian Tupin +6 more
wiley +1 more source
A comparison of recombinant Hirudin with Heparin for the treatment of acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators [PDF]
, 1996 BACKGROUND: Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a potent, direct thrombin inhibitor, recombinant hirudin, with that of heparin (an indirect antithrombin agent) in patients ...
Simoons, M.L. (Maarten)
core +6 more sources