Platelets, 2020 Point of care testing of residual effect of antiplatelet therapy in trauma patients or during major surgery may result in improved clinical management of significant bleeding. We included 121 healthy individuals (57 females and 64 males, aged 22–65 years)
Peter H. Nissen +2 more
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Hirudotherapy /Leech therapy: Applications and Indications in Surgery
Archives of Clinical and Experimental Surgery, 2012 Hirudotherapy (HT) is the application of medicinal leeches (Hirudo medicinalis) for therapeutic use. It is one of the oldest remedies, being employed by various medicinal practitioners.
Swaid Abdullah +3 more
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Malignant atrophic papulosis treated with eculizumab and hirudin: a fatal case report and literature review [PDF]
Frontiers in Cardiovascular MedicineBackgroundMalignant atrophic papulosis (MAP) is a rare obliterative vasculopathy whose etiology and pathophysiological mechanisms remain unknown, and the treatment is still empirical. It can involve multiple systems, especially the gastrointestinal tract
Linna Yu +9 more
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Comparison of leeching and heparin therapy in management of acute venous congestion of limbs in rat
Pharmaceutical and Biomedical Research, 2016 Acute venous congestion leads to blood stasis in the tissue and impaired blood perfusion. Using medicinal leech is an old method for reducing tissue congestion.
Seyed Abdollah Mousavi +4 more
doaj +1 more source
Lepirudin in the management of patients with heparin-induced thrombocytopenia
Biologics: Targets & Therapy, 2008 Sirak PetrosDepartment of Internal Medicine, University of Leipzig, Leipzig, GermanyAbstract: Lepirudin, a recombinant hirudin, is a direct irreversible thrombin inhibitor by binding to both free and clot-bound thrombin.
Sirak Petros
doaj +1 more source
, 2022 Most patients are at high risk of thrombosis during cancer treatment. However, the major discrepancy in the therapeutic mechanisms and microenvironment between tumors and thrombosis makes it challenging for a panacea to treat cancer while being able to ...
Weiyun Zhang (131905) +6 more
core +2 more sources
Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial. [PDF]
Health Sci RepABSTRACT Background and Aims Male infertility, often characterized by impaired sperm parameters, remains a significant clinical challenge. This study aimed to evaluate the efficacy and safety of hirudotherapy (medicinal leech therapy) in improving sperm quality parameters in men with idiopathic infertility.
Abtahi-Forooshani MS +3 more
europepmc +2 more sources
Beeinflussen die Antikoagulantien Heparin und Hirudin die Aktivierung des plasmatischen Gerinnungssystems unter kontinuierlicher Nierenersatztherapie [PDF]
, 2023 Die plasmatische Gerinnungshemmung ist entscheidend bei akutem Nierenversagen mit Notwendigkeit zur kontinuierlicher Nierenersatztherapie. Die Antikoagulation mit Heparin stellt eine Alternative zur Citrat- Antikoagulation dar.
Yilmaz, Kadir
core +1 more source
Traditional Chinese Medicinal Leech Induces Apoptosis and Autophagy in Glioblastoma by SGK1/Caspase-3 and PI3K/AKT/mTOR Pathway. [PDF]
CNS Neurosci TherSchematic representation of the underlying molecular mechanisms by which leech mediates apoptosis and autophagy through SGK1/Caspase‐3 and PI3K/AKT/mTOR pathways to inhibit glioblastoma. ABSTRACT Background Glioblastoma (GBM) represents the most lethal form of high‐grade glioma, with current therapeutic options proving largely ineffective. Consequently,
Wu S, Zhou Y, Pei Z, Wang Y, Zhang Z.
europepmc +2 more sources
Plasma Fibrinogen Independently Predicts Hypofibrinolysis in Severe COVID-19
Metabolites, 2021 High rates of thrombosis are present in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Deeper insight into the prothrombotic state is essential to provide the best thromboprophylaxis care.
Diana Schrick +3 more
doaj +1 more source