Results 11 to 20 of about 5,082,017 (204)

Intermittent Hirudin Versus Continuous Heparin for Anticoagulation in Continuous Renal Replacement Therapy

Renal Failure, 2004
Besides possible bleeding complications a further problem in anticoagulation during continuous renal replacement therapy (CRRT) is the development of heparin-induced thrombocytopenia type II (HIT II) where further anticoagulation with heparin is contraindicated.
Hein OV, von Heymann C, Diehl T, Ziemer S, Ronco C, Morgera S, Siebert G, Kox WJ, Neumayer HH, Spies C   +9 more
openaire   +3 more sources

Medicinal leech therapy—an overall perspective

Integrative Medicine Research, 2017
Complementary medicine methods have a long history, but modern medicine has just recently focused on their possible modes of action. Medicinal leech therapy (MLT) or hirudotherapy, an old technique, has been studied by many researchers for possible ...
Ali K. Sig, Mustafa Guney, Aylin Uskudar Guclu, Erkan Ozmen   +3 more
doaj   +2 more sources

Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side‐effects after radiation therapy and as countermeasure against radiation exposure [PDF]

Journal of Thrombosis and Haemostasis, 2004
The small bowel is a dose-limiting normal tissue in radiation therapy of malignancies in the abdomen and pelvis, as well as an important determinant of survival after non-therapeutic radiation exposure. Irradiation of normal tissues, including intestine, causes loss of vascular thromboresistance and upregulation of thrombin receptors. Radiation-induced
J, Wang, H, Zheng, X, Ou, C M, Albertson, L M, Fink, J-M, Herbert, M, Hauer-Jensen   +6 more
openaire   +3 more sources

Study on the mechanism of hirudin multi target delaying renal function decline in chronic kidney disease based on the "gut-kidney axis" theory. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
The disorder of the “gut-kidney axis” exacerbates renal function decline in chronic kidney disease (CKD), and current CKD therapy is insufficient to address this issue. Hirudin has a palliative effect on the decline of renal function.
Long C, Zhang C, Xie Y.
europepmc   +2 more sources

988-4 Hemorrhagic Stroke Associated with High aPTTs Following Thrombolytic Therapy and Heparin or Hirudin

Journal of the American College of Cardiology, 1995
In GUSTO lla, 2564 patients with acute coronary syndrome with ST deviation and symptoms within 12 hours were randomized to hirudin (0.6 mg/kg bolus, 0.6 mg/kg/hr infusion with out adjustment) or IV heparin (5,000 U bolus, 1100 to 1300 U/hr adjusted tD a target aPTF of 60–90 seconds) for 3–5 days.
Granger, Cristopher, Van de Wert, Frans, Horrigan, Mark, Califf, Robert, Woodlief, Lynn, Topol, Eric   +5 more
openaire   +2 more sources

Effects of thrombolytic therapy in acute inferior myocardial infarction with or without right ventricular involvement. HIT-4 Trial Group. Hirudin for Improvement of Thrombolysis.

Journal of the American College of Cardiology, 1998
This study assessed the prognostic impact of right ventricular involvement (RVI) in streptokinase-treated patients with inferior acute myocardial infarction (AMI) stratified for small or large AMI.Only scant data exist from small studies about the impact of reperfusion therapy on survival in patients with RVI during inferior AMI.Right ventricular ...
U, Zeymer, K L, Neuhaus, K, Wegscheider, U, Tebbe, P, Molhoek, R, Schröder   +5 more
openaire   +3 more sources

Pathogen-reduced plasma, cryoprecipitate reduced for therapeutic plasma exchange. [PDF]

Transfusion
Abstract Background Therapeutic plasma exchange (TPE) for thrombotic thrombocytopenic purpura (TTP) and auto‐immune disorders involves repeated patient exposure to allogenic plasma with the risk of transfusion‐transmitted infection (TTI).
Tupin F, Mouriaux C, Hechler B, Kaastrup K, Yegneswaran S, Corash L, Mangin PH.   +6 more
europepmc   +2 more sources

Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Male infertility, often characterized by impaired sperm parameters, remains a significant clinical challenge. This study aimed to evaluate the efficacy and safety of hirudotherapy (medicinal leech therapy) in improving sperm quality parameters in men with idiopathic infertility.
Abtahi-Forooshani MS, Roozbehani S, Fatemi M, Noori A.   +3 more
europepmc   +2 more sources

Traditional Chinese Medicinal Leech Induces Apoptosis and Autophagy in Glioblastoma by SGK1/Caspase-3 and PI3K/AKT/mTOR Pathway. [PDF]

CNS Neurosci Ther
Schematic representation of the underlying molecular mechanisms by which leech mediates apoptosis and autophagy through SGK1/Caspase‐3 and PI3K/AKT/mTOR pathways to inhibit glioblastoma. ABSTRACT Background Glioblastoma (GBM) represents the most lethal form of high‐grade glioma, with current therapeutic options proving largely ineffective. Consequently,
Wu S, Zhou Y, Pei Z, Wang Y, Zhang Z.
europepmc   +2 more sources

Determinants of reduced antiplatelet effect of aspirin in patients with stable coronary artery disease. [PDF]

PLoS ONE, 2015
Aspirin is a cornerstone in management of coronary artery disease (CAD). However, considerable variability in the antiplatelet effect of aspirin has been reported.To investigate independent determinants of reduced antiplatelet effect of aspirin in stable
Sanne Bøjet Larsen, Erik Lerkevang Grove, Søs Neergaard-Petersen, Morten Würtz, Anne-Mette Hvas, Steen Dalby Kristensen   +5 more
doaj   +1 more source