Results 21 to 30 of about 595 (138)

Pathogen‐reduced plasma, cryoprecipitate reduced for therapeutic plasma exchange

Transfusion, Volume 66, Issue 4, Page 664-676, April 2026.
Abstract Background Therapeutic plasma exchange (TPE) for thrombotic thrombocytopenic purpura (TTP) and auto‐immune disorders involves repeated patient exposure to allogenic plasma with the risk of transfusion‐transmitted infection (TTI).
Florian Tupin, Clarisse Mouriaux, Beatrice Hechler, Kaja Kaastrup, Subra Yegneswaran, Laurence Corash, Pierre H. Mangin   +6 more
wiley   +1 more source

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures, Volume 7, Issue 3, March 2026.
Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
wiley   +1 more source

Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Male infertility, often characterized by impaired sperm parameters, remains a significant clinical challenge. This study aimed to evaluate the efficacy and safety of hirudotherapy (medicinal leech therapy) in improving sperm quality parameters in men with idiopathic infertility.
Mozhde‐Sadat Abtahi‐Forooshani, Shahla Roozbehani, Mahnoosh Fatemi, Ali Noori   +3 more
wiley   +1 more source

Retention of critical platelet hemostatic functions of amotosalen‐UVA pathogen‐reduced cryoprecipitated fibrinogen complex

Transfusion, Volume 66, Issue 2, Page 393-404, February 2026.
Abstract Background Cryoprecipitate Anti‐Haemophilic Factor (CRYO‐AHF) is enriched for fibrinogen, VWF, FVIII, FXIII and fibronectin, but has short post‐thaw expiration due to risk of transfusion‐transmitted infection (TTI) limiting availability for rapid treatment.
Florian Tupin, Clarisse Mouriaux, Michelle Gatmaitan, Kaja Kaastrup, Subramanian Yegneswaran, Laurence Corash, Pierre H. Mangin   +6 more
wiley   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, Volume 13, Issue 4, 19 January 2026.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Mechanism of the inhibition of α‐thrombin by hirudin‐derived fragments hirudin(1–47) and hirudin(45–65) [PDF]

European Journal of Biochemistry, 1991
The kinetic mechanism of the inhibition of α‐thrombin by hirudin was analyzed using the hirudin‐derived fragments hirudin(1–47) and hirudin(45–65). Previously, these fragments have been shown to interact with α‐thrombin at distinct sites inhibiting thrombin‐mediated clot formation.
T, Schmitz, M, Rothe, J, Dodt
openaire   +2 more sources

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

Small, Volume 22, Issue 1, 2 January 2026.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha, Yeonji Kim, Subin Park, Hu‐Lin Jiang, Jae‐Young Lee, Daesik Kim, Jee‐Heon Jeong   +6 more
wiley   +1 more source

Testicular Compartment Syndrome Post Bilateral Microdissection Testicular Sperm Extraction: A Case Report and Review of the Current Literature

Case Reports in Urology, Volume 2026, Issue 1, 2026.
Background Testicular compartment syndrome (TCS) is a rare phenomenon with around 14 cases reported in the literature. It occurs when extraluminal compression or increased venous resistance leads to raised intratesticular pressure. The fibrous tunica albuginea covering the testes does not distend, meaning the pressure is not relieved and compartment ...
Catherine Larard, Katie McComb, Ivo Donkov, Alberto Coscione, Panagiotis Nikolinakos, Karl H. Pang, Suraiya Saleem   +6 more
wiley   +1 more source

Laryngeal Leech as a Live Foreign Body: Case Reports and a Safe Removal Technique

Case Reports in Otolaryngology, Volume 2026, Issue 1, 2026.
Leech infestation in the larynx is a rare condition with serious implications due to airway obstruction and persistent bleeding. This report presents two cases of dysphonia and hemoptysis caused by laryngeal leeches after consuming contaminated water.
Mahdieh Mohebbi, Ali Ghasemi, Saeed Sohrabpour, Reza Erfanian, Farrokh Heidari, Dina Mousavi-Asl, Benyamin Mousavi-Asl, Raut Nivedita   +7 more
wiley   +1 more source