Results 21 to 30 of about 816 (186)
Recombinant hirudin: kinetic mechanism for the inhibition of human thrombin [PDF]
, 2017 Recombinant hirudin variant-2(Lys47 ), was found to be a competitive inhibitor of human α-thrombin with respect to peptidyl p-Miitroanilide substrates.
Hofsteenge, Jan, Stone, Stuart R.
core
British Journal of Haematology, EarlyView.Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov +15 more
wiley +1 more source
Mikrokalorimetrische Studien zum Verständnis der thermodynamischen und strukturellen Eigenschaften von Inhibitoren der Blutgerinnungskaskade [PDF]
, 2005 Genauere Kenntnisse über die Struktur-Wirkungs-Beziehungen sind essentiell für das Design neuer Leitstrukturen und deren Optimierung. Mittlerweile wird vielfach versucht, eine Leitstruktur unter zu Hilfenahme der Kristallstruktur des Zielproteins, das ...
Fokkens, Jasmine, Klebe, Gerhard (Prof.)
core +1 more source
Albumin Restores Endothelial Cell Mitochondrial Morphology in Patients With Decompensated Cirrhosis
Liver International, Volume 46, Issue 5, May 2026.ABSTRACT Background & Aims Endothelial cell (EC) activation is a critical driver of disease progression in cirrhosis, contributing to acute decompensation (AD) and acute‐on‐chronic liver failure (ACLF). Although human albumin administration improves EC function in cirrhotic patients with hypoalbuminemia, its direct effects on ECs remain unclear.
Susan E. Fischer +5 more
wiley +1 more source
Scrotal Hirudiniasis: The Mysterious Migration of a Leech Into the Scrotum: A Case Report
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Hirudiniasis, or leech infestation, is a rare parasitic condition typically involving external skin or mucosal surfaces. We report a case of scrotal hirudiniasis, an 11 cm long leech discovered within the scrotal sac of a 15‐year‐old male.
Pranto Chakroborty, Md. Abdul Quadir
wiley +1 more source
Structure-activity relationship studies on O-sulfated Hirudins [PDF]
, 1998 Thesis (Ph. D. in Agriculture)--University of Tsukuba, (B), no.
Muramatsu Ryo, 村松 了
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Pathogen‐reduced plasma, cryoprecipitate reduced for therapeutic plasma exchange
Transfusion, Volume 66, Issue 4, Page 664-676, April 2026.Abstract Background Therapeutic plasma exchange (TPE) for thrombotic thrombocytopenic purpura (TTP) and auto‐immune disorders involves repeated patient exposure to allogenic plasma with the risk of transfusion‐transmitted infection (TTI).
Florian Tupin +6 more
wiley +1 more source
Expression, purification and characterization of recombinant targeting bifunctional hirudin in Pichia pastoris [PDF]
, 2011 A recombinant targeting bifunctional hirudin was expressed in the yeast Pichia pastoris. In order to decrease the side effects of hirudin and increase its activity to prevent arterial thrombus, we fused a factor Xa (FXa) recognition sequence into N’ of ...
Chen, G +5 more
core +2 more sources
Small Structures, Volume 7, Issue 3, March 2026.Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan +9 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 2, February 2026.ABSTRACT Background and Aims Male infertility, often characterized by impaired sperm parameters, remains a significant clinical challenge. This study aimed to evaluate the efficacy and safety of hirudotherapy (medicinal leech therapy) in improving sperm quality parameters in men with idiopathic infertility.
Mozhde‐Sadat Abtahi‐Forooshani +3 more
wiley +1 more source