Results 181 to 190 of about 310,272 (392)

Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX‐622

Allergy, EarlyView.
SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy, Laura Vitale, Thomas O'Neill, Deena M. Maurer, Linda Malenchek, Andrea Crocker, Colleen Patterson, Laura Mills‐Chen, Virginia Saley, Nicole M. Antczak, James M. Boyer, Kelly M. McManus, Noe Rico Montanari, Russell A. Hammond, Joel Goldstein, Lawrence J. Thomas, Tibor Keler, Diego Alvarado   +17 more
wiley   +1 more source

Non‐Allergic Urticarial Skin Reactions Associated With MOv18 IgE, a First‐In‐Class IgE Antibody Recognising Folate Receptor Alpha

Allergy, EarlyView.
MOv18 IgE, the first‐in‐class IgE antibody targeting the cancer antigen folate receptor alpha (FR⍺) showed early signs of efficacy and was well tolerated in a first‐in‐human clinical trial, with transient urticarial skin reactions as the most common toxicity.
Chara Stavraka, Jitesh Chauhan, Silvia Crescioli, Sheila M. McSweeney, Amy Pope, Cheryl Gillett, Ashley Di Meo, Ioannis Prassas, Roman Laddach, Katie Stoker, Alexandra J. McCraw, Rebecca Adams, Thomas J. Tull, Nabeel Naban, Zena Willsmore, Kristina V. Semkova, Clive E. H. Grattan, John McGrath, Stephen J. Till, Christopher J. Corrigan, Rebecca Kristeleit, Sophia Tsoka, Eleftherios P. Diamandis, Katie E. Lacy, Sarah Pinder, Debra H. Josephs, James Spicer, Heather J. Bax, Sophia N. Karagiannis   +28 more
wiley   +1 more source

Liver‐directed drugs for transthyretin‐mediated amyloidosis

Journal of the Peripheral Nervous System, Volume 27, Issue 4, Page 228-237, December 2022., 2022
Abstract Transthyretin‐mediated amyloidosis (ATTR) is a rare, under‐recognized, progressively debilitating, fatal disease caused by the aggregation and extracellular deposition of amyloid transthyretin (TTR) fibrils in multiple organs and tissues throughout the body.
Thomas H. Brannagan 3rd, John L. Berk, Julian D. Gillmore, Mathew S. Maurer, Márcia Waddington‐Cruz, Marianna Fontana, Ahmad Masri, Laura Obici, Michela Brambatti, Brenda F. Baker, Lisa A. Hannan, Gustavo Buchele, Nick J. Viney, Teresa Coelho, Jose Nativi‐Nicolau   +14 more
wiley   +1 more source

Comparative Evaluation of an Allergen Exposure Chamber and Nasal Allergen Challenge Versus In‐Field Symptom Assessment in Patients With Allergic Rhinitis Triggered by Timothy Grass Pollen

Allergy, EarlyView.
This study validated AEC and NAC allergen provocation‐derived symptom severity against natural exposure during the timothy grass pollen season in allergic rhinitis patients. Both AEC and NAC tests can be effectively applied for symptom severity assessment in allergy diagnostics.
Magdalena Zemelka‐Wiacek, Anna Kosowska, Oliver Pfaar, Ioana Agache, Krzysztof Kujawa, Marek Jutel   +5 more
wiley   +1 more source

The histamine content of allergic and nonallergic human nasal mucous membrane with simultaneous observations on the eosinophils

, 1953
James D. Baxter, B. Rose
openalex   +2 more sources

HISTAMINE AND 5-HYDROXYTRYPTAMINE IN THE BLOOD OF INFANTS AND CHILDREN [PDF]

, 1959
Ross G. Mitchell, Rosemary Cass
openalex   +1 more source

Assessment of Toxic Histamine Contents in Processed Cheeses and the Effect of Salt and pH Levels on the Amount of Histamine [PDF]

Journal of Food Quality and Hazards Control
Background: Histamine is a chemical released by the body's immune system in response to allergens, which causes messages to be sent between different cells.
T. Heidari, G. Jahed Khaniki, P. Sadighara, N. Shariatifar   +3 more
doaj  

Definition and classification of the histamine-release response to drugs in anaesthesia and surgery: studies in the conscious human subject [PDF]

, 1982
Doenicke, A., Grote, B., Lorenz, Wilfried, Neugebauer, E., Ohmann, C., Schöning, B.   +5 more
core   +1 more source

OBSERVATIONS ON THE HUMAN GASTRO‐DUODENAL SECRETIONS WITH SPECIAL REFERENCE TO THE ACTION OF HISTAMINE [PDF]

, 1923
R. K. S. Lim, Alister R. Matheson, W. Schlapp   +2 more
openalex   +1 more source

Increased formation of histamine in the pregnant rat

, 1958
G. Kahlson, Elsa Rosengren, H. Westling
openalex   +2 more sources