Phosphatase Inhibition Attenuates the Negative Inotropic Effect of Muscarinic Receptors in the Presence of Serotonin. [PDF]
Curr Issues Mol BiolSchwarz R +4 more
europepmc +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Spectrofluorimetric Method for Sensitive Histamine Detection Using Europium Complexation. [PDF]
ACS OmegaKamel KB +5 more
europepmc +1 more source
Need to Assess On‐Demand Versus Continuous Treatment in Allergic Rhinitis in ARIA‐EAACI Guidelines
Allergy, EarlyView.
Jean Bousquet +7 more
wiley +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Purified Compounds from <i>Phyllanthus amarus</i> Schum. & Thonn. Inhibit Mast Cell Degranulation via Modulation of Syk/PLCγ Signaling. [PDF]
MoleculesVo TS, My VTN, Luan PVH, Ngo DH.
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley +1 more source
Predicting Oral Food Challenge Outcomes in Children with Suspected Cow's Milk Allergy: Clinical Utility of Casein-Specific IgE and Skin Test Ratios. [PDF]
NutrientsDemir Şahin F +3 more
europepmc +1 more source