Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain [PDF]
Biomedicines, 2023 Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabolism.
Gülşah Okutan +8 more
doaj +8 more sources
Standardization of a colorimetric technique for determination of enzymatic activity of diamine oxidase (DAO) and its application in patients with clinical diagnosis of histamine intolerance [PDF]
World Allergy Organization Journal, 2020 Background: Diamine Oxidase (DAO) has an essential role for degradation of exogenous histamine in the intestine; thus, histamine intolerance (HI) mainly has been correlated to a low concentration and/or activity of this enzyme. The objective of the study
Ferrer P, Carla Bastías
exaly +4 more sources
Diamine Oxidase and Gastrointestinal Diseases [PDF]
BiomoleculesHistamine plays an essential role in gastrointestinal physiology and immune control, while its balance in the intestinal environment is largely maintained through degradation by diamine oxidase (DAO), a copper-dependent enzyme mainly produced by ...
Paulina Żybul +3 more
doaj +3 more sources
Diamine oxidase (DAO) activity increase in sera of tumor patients: An unreliable marker
International Journal of Biological Markers, 1989 Circulating diamine oxidase (DAO) (EC 1.4.3.6) activity was determined in the sera of patients with different malignant tumors. The increase in this activity only partially reflected tumor activity so it is presumably unreliable as a diagnostic marker ...
M. Romano, R. Pasquinelli
exaly +4 more sources
Multivariate statistical optimization of the ultrasonic-assisted extraction of diamine oxidase (DAO) from pea sprout [PDF]
Ultrasonics SonochemistryPea sprouts can provide a plant-based alternative to the commonly used pork kidney as a source of diamine oxidase (DAO), an enzyme used as a dietary supplement to prevent symptoms of histamine intolerance.
M. Khanlar +3 more
doaj +5 more sources
Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABA<sub>A</sub> Receptors That Modulate Dorsal Root Ganglia Neuron Excitability. [PDF]
GliaMechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Jiménez-Barrios N +7 more
europepmc +2 more sources
Clinical and Mechanistic Association Between Intestinal Permeability and the Gut Microbiome in Cirrhosis: Role of Phascolarctobacterium. [PDF]
United European Gastroenterol JABSTRACT Background In patients with liver cirrhosis, intestinal permeability and the composition of the gut microbiome are altered. Thus, the microbiome might be a therapeutic target for the treatment of both liver diseases and intestinal permeability.
Haller R +10 more
europepmc +2 more sources
Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the AOC1 gene: a randomized double-blind placebo-controlled study [PDF]
Sleep Medicine: XObjective: This exploratory study was designed to assess the effect of a diamine oxidase (DAO) enzyme supplement on insomnia symptoms in patients with alterations of the AOC1 gene, which encodes the DAO enzyme.
Júlia Ferrer-Garcia +6 more
doaj +2 more sources
A case series of diamine oxidase deficiency misdiagnosed as anxiety or panic attacks in patients with tachycardia [PDF]
Indian Journal of PsychiatryBackground: Diamine oxidase (DAO) deficiency, a key marker of histamine intolerance (HIT), often mimics anxiety or panic disorders, leading to a misdiagnoses and delayed treatment.
Ilkay Keskinel
doaj +2 more sources
Markedly Increased Diamine Oxidase During Acute Anaphylaxis Is Associated With an Underlying Clonal Mast Cell Disorder. [PDF]
Clin Exp AllergyWe provide the first evidence that pronounced release of DAO during anaphylaxis is restricted to patients with clonal mast cell disorder. This finding offers possible functional support for the reported association between KIT p.D816V and anaphylaxis severity.
Rijavec M +5 more
europepmc +2 more sources