Results 1 to 10 of about 7,332 (178)

Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3 [PDF]

Open Biology, 2020
Zinc-α2-glycoprotein (ZAG) is a major plasma protein whose levels increase in chronic energy-demanding diseases and thus serves as an important clinical biomarker in the diagnosis and prognosis of the development of cachexia.
Matthias Romauch
doaj   +4 more sources

Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy [PDF]

International Journal of Retina and Vitreous, 2021
Background Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20–65 years and can go undetected until vision is irreversibly lost.
David S. Boyer, Joerg F. Rippmann, Michael S. Ehrlich, Remko A. Bakker, Victor Chong, Quan Dong Nguyen   +5 more
doaj   +2 more sources

Human Copper-Containing Amine Oxidases in Drug Design and Development [PDF]

Molecules, 2020
Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3 ...
Serhii Vakal, Sirpa Jalkanen, Käthe M. Dahlström, Tiina A. Salminen   +3 more
doaj   +4 more sources

A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis [PDF]

Nature Communications, 2023
Non-alcoholic steatohepatitis (NASH) is a progressive, inflammatory liver disease with no approved pharmacological treatment. This Phase IIa, double-blind, placebo-controlled, multicentre trial (ClinicalTrials.gov: NCT03166735) investigated ...
Philip N. Newsome, Arun J. Sanyal, Guy Neff, Jörn M. Schattenberg, Vlad Ratziu, Judith Ertle, Jasmin Link, Alison Mackie, Corinna Schoelch, Eric Lawitz, BI 1467335 NASH Phase IIa trial team   +10 more
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Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors

Medicines, 2019
Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper ...
Christian Carpéné, Nathalie Boulet, Alice Chaplin, Josep Mercader   +3 more
doaj   +3 more sources

Real-time capture of domain movements during copper amine oxidase catalysis by mix-and-inject serial crystallography [PDF]

Nature Communications
Protein dynamics play a crucial role in various physiological functions, including enzyme catalysis. To explore conformational changes during enzyme catalysis, we conduct mix-and-inject serial crystallography, an advanced technique to capture time ...
Takeshi Murakawa, Mamoru Suzuki, Kenji Fukui, Tetsuya Masuda, Eiichi Mizohata, Ikuko Miyahara, Ikuya Kurauchi, Taiki Murakami, Himawari Matsunaga, Yoshiki Montawa, Norie Nakajima, Toshinori Oozeki, Katsuki Sakai, Teikoku Son, Takehiro Higuchi, Tomoko Sunami, Tetsunari Kimura, Kensuke Tono, Tomoyuki Tanaka, Michihiro Sugahara, Toshi Arima, Luo Fangjia, Jungmin Kang, Rie Tanaka, So Iwata, Eriko Nango, Takehiko Tosha, Takato Yano, Katsuyuki Tanizawa, Toshihide Okajima   +29 more
doaj   +2 more sources

EctoShed: a novel gene delivery platform for functional analysis of adipocyte-shed proteoforms [PDF]

BMC Research Notes
Objective The proteolytic cleavage of membrane-bound proteins, ectodomain shedding, functionally expands the reservoir of proteins/peptides available for endocrine crosstalk, and metabolic regulation.
Ana Rita Tavanez, Nadia Meincke Egedal, Natasa Stanic, Hande Topel, Jan-Wilhelm Kornfeld   +4 more
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The tree of life of copper-containing amine oxidases

Frontiers in Plant Science
Copper-containing amine oxidases (CuAOs) catalyze the terminal oxidation of polyamines (PAs), producing ammonium, an aminoaldehyde, and hydrogen peroxide (H2O2). Plant CuAOs are induced by stress-related hormones such as methyl-jasmonate (MeJA), abscisic
Zaibao Zhang, Tao Xiong, Kejia Li, Kexin Huang, Siyu Wu, Luhui Wu   +5 more
doaj   +3 more sources

Pan-cancer analysis reveals AOC3 as a potential therapeutic biomarker for colorectal cancer [PDF]

Discover Oncology
Amine oxidase copper containing 3 (AOC3) had been reported to play an important regulatory role in the biological functional pathways, immune microenvironment and cellular function.
Guanlong Wang, Lidan Zhu, Ling Lu, Guangyang Wu, Bangjie Wang, Changjun Yu   +5 more
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Current status of neutron crystallography in structural biology

Biophysics and Physicobiology, 2022
Hydrogen atoms and hydration water molecules in proteins are essential for many biochemical processes, especially enzyme catalysis. Neutron crystallography enables direct observation of hydrogen atoms, and reveals molecular recognition through hydrogen ...
Fumiaki Kono, Kazuo Kurihara, Taro Tamada   +2 more
doaj   +1 more source