Results 21 to 30 of about 2,838,820 (225)

SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer

Cell Death and Disease, 2022
Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of tumors. Nevertheless, there have been no investigations of AOC1 and its regulatory mechanism in prostate cancer.
Yinghui Ding, Yuankang Feng, Zhenlin Huang, Yu Zhang, Xiang Li, Ruoyang Liu, Hao Li, Tao Wang, Yafei Ding, Zhankui Jia, Jinjian Yang   +10 more
doaj   +1 more source

Potential role of NADPH-oxidase in early steps of lead-induced oxidative burst in Vicia faba roots [PDF]

, 2008
The mechanism of oxidative burst induced by lead in Vicia faba excised roots was investigated by luminol-dependent chemiluminescence. Results showed that lead triggered a rapid and dose-dependent increase in chemiluminescence production.
Perchet, Geoffrey-Thibault, Cecchi, M., Silvestre, Jérôme, Pinelli, Eric, Pourrut, Bertrand, Cecchi, Marie, Guiresse, Agnès Maritchù, Guiresse, Maritxu   +7 more
core   +1 more source

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

Biomedicines, 2021
SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRPV1 ...
Ádám István Horváth, Nikolett Szentes, Valéria Tékus, Maja Payrits, Éva Szőke, Emőke Oláh, András Garami, Eszter Fliszár-Nyúl, Miklós Poór, Cecília Sár, Tamás Kálai, Szilárd Pál, Krisztina Percze, Éva Nagyné Scholz, Tamás Mészáros, Blanka Tóth, Péter Mátyus, Zsuzsanna Helyes   +17 more
doaj   +1 more source

Bioconversion of Airborne Methylamine by Immobilized Recombinant Amine Oxidase from the Thermotolerant Yeast Hansenula polymorpha

The Scientific World Journal, 2014
Aliphatic amines, including methylamine, are air-pollutants, due to their intensive use in industry and the natural degradation of proteins, amino acids, and other nitrogen-containing compounds in biological samples.
Sasi Sigawi, Marina Nisnevitch, Oksana Zakalska, Andriy Zakalskiy, Yeshayahu Nitzan, Mykhailo Gonchar   +5 more
doaj   +1 more source

Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study

Frontiers in Genetics, 2023
Introduction: The amine oxidase copper-containing 1 (AOC1) gene encodes for the diamine oxidase (DAO) enzyme. DAO is an enzyme that catabolizes some molecules, including histamine, and is the degradative enzyme in the polyamine catabolic pathway that is ...
Gülşah Okutan, Teresa Perucho Alcalde, Teresa Perucho Alcalde, Eva Ruiz Casares, Eva Ruiz Casares, Bruno F. Penadés, Guerthy Melissa Sánchez Niño, Ana Terrén Lora, Sara López Oliva, Lorena Torrente Estríngana, Adriana Duelo, Ismael San Mauro Martín   +11 more
doaj   +1 more source

Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep

BMC Genomics, 2023
Background The detection of selective traits in different populations can not only reveal current mechanisms of artificial selection for breeding, but also provide new insights into phenotypic variation in new varieties and the search for genes ...
Huibin Shi, Taotao Li, Manchun Su, Huihui Wang, Qiao Li, Xia Lang, Youji Ma   +6 more
doaj   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Axial Boron Coordination Reconstructs Stereostructure of Cu Single‐Atom Nanozymes for Efficient Water‐Phase Chemical Sensing

Angewandte Chemie, EarlyView.
Sun et al. proposed an axial boron coordination strategy to reconstruct the stereostructure of Cu SAzymes and enable them to serve as efficient laccase mimics for high‐throughput smart sensor array detection of phenolic pollutants in water phases. ABSTRACT Developing single‐atom nanozymes with stereoconfigurations is a new paradigm for biomimetic ...
Qijun Sun, Hongyu Shi, Si Liu, Ziping Li, Yu Yang, Fengwang Li, Wenli Wu, Qiongzheng Hu, Kang Liang   +8 more
wiley   +2 more sources

Inhibition of copper-containing amine oxidase by oximes.

Chemical and Pharmaceutical Bulletin, 1988
The inhibitory effects of twelve oxime compounds on the activity of bovine serum monoamine oxidase (copper-containing amine oxidase, E.C. 1.4.3.6) were assayed in vitro. The most potent inhibitor among the compounds examined was 2-butanone oxime, of which the 50% inhibiting concentration in the reaction mixture was 7×10-6 M.
HIRAOKA, ATSUSHI, OHTAKA, JUNKO, KOIKE, SATORU, TSUBOI, YUKO, TSUCHIKAWA, SHINPEI, MIURA, ISAO   +5 more
openaire   +3 more sources

Exploring the cellular and molecular differences between ovarian clear cell carcinoma and high-grade serous carcinoma using single-cell RNA sequencing and GEO gene expression signatures

Cell & Bioscience, 2023
The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC).
Dan Guo, Sumei Zhang, Yike Gao, Jinghua Shi, Xiaoxi Wang, Zixin Zhang, Yaran Zhang, Yuming Wang, Kun Zhao, Mei Li, Anqi Wang, Pan Wang, Yanqin Gou, Miao Zhang, Meiyu Liu, Yuhan Zhang, Rui Chen, Jian Sun, Shu Wang, Xunyao Wu, Zhiyong Liang, Jie Chen, Jinghe Lang   +22 more
doaj   +1 more source