Results 21 to 30 of about 7,332 (178)

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

Biomedicines, 2021
SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRPV1 ...
Ádám István Horváth, Nikolett Szentes, Valéria Tékus, Maja Payrits, Éva Szőke, Emőke Oláh, András Garami, Eszter Fliszár-Nyúl, Miklós Poór, Cecília Sár, Tamás Kálai, Szilárd Pál, Krisztina Percze, Éva Nagyné Scholz, Tamás Mészáros, Blanka Tóth, Péter Mátyus, Zsuzsanna Helyes   +17 more
doaj   +1 more source

Bioconversion of Airborne Methylamine by Immobilized Recombinant Amine Oxidase from the Thermotolerant Yeast Hansenula polymorpha

The Scientific World Journal, 2014
Aliphatic amines, including methylamine, are air-pollutants, due to their intensive use in industry and the natural degradation of proteins, amino acids, and other nitrogen-containing compounds in biological samples.
Sasi Sigawi, Marina Nisnevitch, Oksana Zakalska, Andriy Zakalskiy, Yeshayahu Nitzan, Mykhailo Gonchar   +5 more
doaj   +1 more source

Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study

Frontiers in Genetics, 2023
Introduction: The amine oxidase copper-containing 1 (AOC1) gene encodes for the diamine oxidase (DAO) enzyme. DAO is an enzyme that catabolizes some molecules, including histamine, and is the degradative enzyme in the polyamine catabolic pathway that is ...
Gülşah Okutan, Teresa Perucho Alcalde, Teresa Perucho Alcalde, Eva Ruiz Casares, Eva Ruiz Casares, Bruno F. Penadés, Guerthy Melissa Sánchez Niño, Ana Terrén Lora, Sara López Oliva, Lorena Torrente Estríngana, Adriana Duelo, Ismael San Mauro Martín   +11 more
doaj   +1 more source

Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep

BMC Genomics, 2023
Background The detection of selective traits in different populations can not only reveal current mechanisms of artificial selection for breeding, but also provide new insights into phenotypic variation in new varieties and the search for genes ...
Huibin Shi, Taotao Li, Manchun Su, Huihui Wang, Qiao Li, Xia Lang, Youji Ma   +6 more
doaj   +1 more source

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

Oxygen‐Tolerant Photo‐Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA‐ATRP) for High‐Throughput Synthesis of Polymer Bioconjugates

Angewandte Chemie, EarlyView.
Oxygen‐tolerant photo‐induced miniaturized accelerated atom transfer radical polymerization (OPTIMA‐ATRP) in water was developed for the polymerization of hydrophilic (meth)acrylate monomers under ambient or sub‐ambient (4°C) temperature and atmospheric conditions, without prior degassing, in less than 10 min, at an ultra‐small scale (< 50 µL) in ...
Arman Moini Jazani, Roksana Wygoda, Hironobu Murata, Mozhdeh Madadi, Grzegorz Przesławski, Krzysztof Matyjaszewski   +5 more
wiley   +2 more sources

Exploring the cellular and molecular differences between ovarian clear cell carcinoma and high-grade serous carcinoma using single-cell RNA sequencing and GEO gene expression signatures

Cell & Bioscience, 2023
The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC).
Dan Guo, Sumei Zhang, Yike Gao, Jinghua Shi, Xiaoxi Wang, Zixin Zhang, Yaran Zhang, Yuming Wang, Kun Zhao, Mei Li, Anqi Wang, Pan Wang, Yanqin Gou, Miao Zhang, Meiyu Liu, Yuhan Zhang, Rui Chen, Jian Sun, Shu Wang, Xunyao Wu, Zhiyong Liang, Jie Chen, Jinghe Lang   +22 more
doaj   +1 more source

Inhibition of copper-containing amine oxidase by oximes.

Chemical and Pharmaceutical Bulletin, 1988
The inhibitory effects of twelve oxime compounds on the activity of bovine serum monoamine oxidase (copper-containing amine oxidase, E.C. 1.4.3.6) were assayed in vitro. The most potent inhibitor among the compounds examined was 2-butanone oxime, of which the 50% inhibiting concentration in the reaction mixture was 7×10-6 M.
HIRAOKA, ATSUSHI, OHTAKA, JUNKO, KOIKE, SATORU, TSUBOI, YUKO, TSUCHIKAWA, SHINPEI, MIURA, ISAO   +5 more
openaire   +3 more sources

Ultrasound and microbubble-mediated delivery of miR-424-5p has a therapeutic effect in preeclampsia

Biological Procedures Online, 2023
Objective To determine the influence of ultrasound/microbubble-mediated miR-424-5p delivery on trophoblast cells and the underlying mechanism. Methods Blood pressure and 24-h proteinuria of patients with preeclampsia (PE) were measured as well as the ...
Xudong Wang, Yan Wu, Qinliang Sun, Zhonghui Jiang, Guoying Che, Yangyang Tao, Jiawei Tian   +6 more
doaj   +1 more source

Water Permeates and Plasticizes Amorphous Carbon Dots: Unraveling the Inner Accessibility of the Nanoparticles by Glass Transition Studies

Advanced Materials, EarlyView.
The water permeability of amorphous carbon dots (CDs) is demonstrated by investigating their plasticization. Novel polyamide‐based and amorphous nanoparticles are synthesized by controlling their inner packing density. Water plasticization is evidenced by the decrease of the CDs glass transition temperature with increasing the hydration degree.
Elisa Sturabotti, Valerio Di Lisio, Lucia Cardo, Alessandro Camilli, Estela Moretón Alfonsín, Daniele Cangialosi, Amaia Iturrospe Ibarra, Arantxa Arbe, Maurizio Prato   +8 more
wiley   +1 more source